Detailed information of TA system TA144990

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1028128..1028693
• Replicon: chromosome
• Accession: NZ_CP046818
• Organism: Vibrio metoecus strain 06-2478

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX95_RS17675
• Protein ID: WP_055031532.1
• Coordinates: 1028406..1028693 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D0IIK3
• Locus tag: GPX95_RS17670
• Protein ID: WP_000086649.1
• Coordinates: 1028128..1028409 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX95_RS17645	1024580..1025131	+	552	WP_001894072.1	translation initiation factor IF-3	-
GPX95_RS17650	1025235..1025429	+	195	WP_001885060.1	50S ribosomal protein L35	-
GPX95_RS17655	1025471..1025824	+	354	WP_001138366.1	50S ribosomal protein L20	-
GPX95_RS17660	1025906..1026868	-	963	WP_000841992.1	integron integrase IntIA	-
GPX95_RS17665	1027118..1027918	+	801	WP_055031531.1	BRO-like protein	-
GPX95_RS17670	1028128..1028409	+	282	WP_000086649.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX95_RS17675	1028406..1028693	+	288	WP_055031532.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX95_RS17680	1028842..1029618	+	777	WP_055031533.1	choline kinase	-
GPX95_RS17685	1029864..1030061	+	198	WP_081022490.1	DUF3709 domain-containing protein	-
GPX95_RS17690	1030402..1030854	+	453	WP_055031534.1	GNAT family N-acetyltransferase	-
GPX95_RS17695	1030992..1031309	+	318	WP_000640723.1	heavy metal-binding domain-containing protein	-
GPX95_RS17700	1031324..1031416	+	93	WP_198926205.1	DUF3265 domain-containing protein	-
GPX95_RS17705	1031443..1032105	+	663	WP_055031535.1	DUF4145 domain-containing protein	-
GPX95_RS17710	1032110..1032220	+	111	Protein_877	DUF3265 domain-containing protein	-
GPX95_RS17715	1032265..1032885	+	621	WP_055031536.1	hypothetical protein	-
GPX95_RS17720	1033324..1033434	+	111	WP_086017781.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1024742..1129239	104497
	-	inside	Integron	-	-	1025906..1128911	103005

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10925.68 Da
• Isoelectric Point: 6.4774

>T144990 WP_055031532.1 NZ_CP046818:1028406-1028693 [Vibrio metoecus]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNGVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T144990 NZ_CP062248:4342726-4342899 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10361.93 Da
• Isoelectric Point: 5.1548

>AT144990 WP_000086649.1 NZ_CP046818:1028128-1028409 [Vibrio metoecus]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT144990 NZ_CP062248:4342402-4342698 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0K9UIW4