Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 386655..387205 Replicon chromosome
Accession NZ_CP046816
Organism Vibrio cincinnatiensis strain 1398-82

Toxin (Protein)


Gene name parE Uniprot ID A0A1T4SPA2
Locus tag GPX87_RS14820 Protein ID WP_039428516.1
Coordinates 386906..387205 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag GPX87_RS14815 Protein ID WP_078927668.1
Coordinates 386655..386897 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX87_RS14770 382634..382822 + 189 WP_078927648.1 hypothetical protein -
GPX87_RS14775 383134..383610 - 477 WP_078927649.1 GNAT family N-acetyltransferase -
GPX87_RS14780 384588..384698 - 111 WP_115173931.1 DUF3265 domain-containing protein -
GPX87_RS14785 384755..385003 + 249 WP_000126952.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPX87_RS14790 384993..385283 + 291 WP_000221349.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPX87_RS14795 385332..385448 - 117 WP_113594551.1 DUF3265 domain-containing protein -
GPX87_RS14800 385445..385747 - 303 WP_113594550.1 hypothetical protein -
GPX87_RS14805 385748..385903 - 156 WP_158142139.1 hypothetical protein -
GPX87_RS14810 386449..386562 - 114 WP_115173884.1 DUF3265 domain-containing protein -
GPX87_RS14815 386655..386897 + 243 WP_078927668.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPX87_RS14820 386906..387205 + 300 WP_039428516.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPX87_RS14825 387327..388460 - 1134 WP_078927662.1 ISAs1 family transposase -
GPX87_RS14830 388695..390020 - 1326 WP_115173883.1 group II intron reverse transcriptase/maturase -
GPX87_RS14835 390683..391645 + 963 WP_078925954.1 integron integrase -
GPX87_RS14840 391692..392045 - 354 WP_040992521.1 50S ribosomal protein L20 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 387327..388460 1133


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-55)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11622.26 Da        Isoelectric Point: 9.6429

>T144989 WP_039428516.1 NZ_CP046816:386906-387205 [Vibrio cincinnatiensis]
MHNKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPQNHLK

Download         Length: 300 bp

>T144989 NZ_CP062248:c3693448-3693341 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9192.56 Da        Isoelectric Point: 5.6772

>AT144989 WP_078927668.1 NZ_CP046816:386655-386897 [Vibrio cincinnatiensis]
MYTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNVAKDDLVKGNVVDGKDFLNEL

Download         Length: 243 bp

>AT144989 NZ_CP062248:3693497-3693563 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1T4SPA2

Antitoxin

Source ID Structure

References