Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 384755..385283 | Replicon | chromosome |
| Accession | NZ_CP046816 | ||
| Organism | Vibrio cincinnatiensis strain 1398-82 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0F2I060 |
| Locus tag | GPX87_RS14790 | Protein ID | WP_000221349.1 |
| Coordinates | 384993..385283 (+) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A0F2IA58 |
| Locus tag | GPX87_RS14785 | Protein ID | WP_000126952.1 |
| Coordinates | 384755..385003 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPX87_RS14760 | 379787..380899 | - | 1113 | WP_078927628.1 | hypothetical protein | - |
| GPX87_RS14765 | 381113..381295 | - | 183 | WP_078927629.1 | DUF645 family protein | - |
| GPX87_RS14770 | 382634..382822 | + | 189 | WP_078927648.1 | hypothetical protein | - |
| GPX87_RS14775 | 383134..383610 | - | 477 | WP_078927649.1 | GNAT family N-acetyltransferase | - |
| GPX87_RS14780 | 384588..384698 | - | 111 | WP_115173931.1 | DUF3265 domain-containing protein | - |
| GPX87_RS14785 | 384755..385003 | + | 249 | WP_000126952.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPX87_RS14790 | 384993..385283 | + | 291 | WP_000221349.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPX87_RS14795 | 385332..385448 | - | 117 | WP_113594551.1 | DUF3265 domain-containing protein | - |
| GPX87_RS14800 | 385445..385747 | - | 303 | WP_113594550.1 | hypothetical protein | - |
| GPX87_RS14805 | 385748..385903 | - | 156 | WP_158142139.1 | hypothetical protein | - |
| GPX87_RS14810 | 386449..386562 | - | 114 | WP_115173884.1 | DUF3265 domain-containing protein | - |
| GPX87_RS14815 | 386655..386897 | + | 243 | WP_078927668.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPX87_RS14820 | 386906..387205 | + | 300 | WP_039428516.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPX87_RS14825 | 387327..388460 | - | 1134 | WP_078927662.1 | ISAs1 family transposase | - |
| GPX87_RS14830 | 388695..390020 | - | 1326 | WP_115173883.1 | group II intron reverse transcriptase/maturase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 387327..388460 | 1133 | |
| - | inside | Integron | - | - | 364295..386897 | 22602 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11219.17 Da Isoelectric Point: 10.6296
>T144988 WP_000221349.1 NZ_CP046816:384993-385283 [Vibrio cincinnatiensis]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLENPHVPASKLSGADNMYKIKLRQSGYRLVYQVKDDVIVVTVLAVGK
RERSDVYRSAMKRLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLENPHVPASKLSGADNMYKIKLRQSGYRLVYQVKDDVIVVTVLAVGK
RERSDVYRSAMKRLDD
Download Length: 291 bp
>T144988 NZ_CP062248:3270697-3271161 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9062.38 Da Isoelectric Point: 4.1068
>AT144988 WP_000126952.1 NZ_CP046816:384755-385003 [Vibrio cincinnatiensis]
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAKAYEMMMDRLDDLELLAIARERESEESISVNID
DL
MTARILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAKAYEMMMDRLDDLELLAIARERESEESISVNID
DL
Download Length: 249 bp
>AT144988 NZ_CP062248:3270362-3270697 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F2I060 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0F2IA58 |