Detailed information of TA system TA144987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 364475..365015
• Replicon: chromosome
• Accession: NZ_CP046816
• Organism: Vibrio cincinnatiensis strain 1398-82

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX87_RS14670
• Protein ID: WP_002033296.1
• Coordinates: 364746..365015 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1T4SKS5
• Locus tag: GPX87_RS14665
• Protein ID: WP_032480862.1
• Coordinates: 364475..364753 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX87_RS14645	359486..359707	-	222	Protein_344	transposase	-
GPX87_RS14650	359897..360664	-	768	WP_139364809.1	hypothetical protein	-
GPX87_RS14655	360706..361839	-	1134	WP_078927662.1	ISAs1 family transposase	-
GPX87_RS14660	362074..363399	-	1326	WP_115173883.1	group II intron reverse transcriptase/maturase	-
GPX87_RS14665	364475..364753	+	279	WP_032480862.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GPX87_RS14670	364746..365015	+	270	WP_002033296.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GPX87_RS14675	365150..365857	-	708	WP_078927637.1	hypothetical protein	-
GPX87_RS14680	366043..366600	+	558	WP_078927636.1	hypothetical protein	-
GPX87_RS14685	366724..366912	+	189	WP_139364803.1	hypothetical protein	-
GPX87_RS14690	367638..368489	-	852	WP_158116599.1	IS3 family transposase	-
GPX87_RS14695	368573..368794	-	222	Protein_354	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	360706..361839	1133
	-	inside	Integron	-	-	352272..360664	8392
	-	inside	Integron	-	-	364295..386897	22602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10308.95 Da
• Isoelectric Point: 8.0487

>T144987 WP_002033296.1 NZ_CP046816:364746-365015 [Vibrio cincinnatiensis]
MYSLEYSTQFKKDFKKITKMPISDIIEVGNIISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDDQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T144987 NZ_CP062248:c3227815-3227501 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10053.51 Da
• Isoelectric Point: 6.0643

>AT144987 WP_032480862.1 NZ_CP046816:364475-364753 [Vibrio cincinnatiensis]
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVDAM
LTELTEGKVKNV

Nucleotide

• Length: 279 bp

>AT144987 NZ_CP062248:c3227504-3227088 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SKS5