Detailed information of TA system TA144986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-Phd
• Location: 357401..357948
• Replicon: chromosome
• Accession: NZ_CP046816
• Organism: Vibrio cincinnatiensis strain 1398-82

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPX87_RS14625
• Protein ID: WP_078927641.1
• Coordinates: 357401..357703 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9KM93
• Locus tag: GPX87_RS14630
• Protein ID: WP_000861987.1
• Coordinates: 357691..357948 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX87_RS14590	353382..354044	-	663	WP_078927652.1	Vat family streptogramin A O-acetyltransferase	-
GPX87_RS14595	354163..354615	-	453	WP_078927653.1	hypothetical protein	-
GPX87_RS14600	355383..355898	-	516	WP_115173891.1	hypothetical protein	-
GPX87_RS14605	355975..356064	-	90	WP_078927642.1	DUF3265 domain-containing protein	-
GPX87_RS14610	356761..356871	-	111	Protein_337	DUF3265 domain-containing protein	-
GPX87_RS14615	356868..357155	-	288	WP_078927640.1	hypothetical protein	-
GPX87_RS14620	357275..357391	-	117	Protein_339	DUF3265 domain-containing protein	-
GPX87_RS14625	357401..357703	-	303	WP_078927641.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX87_RS14630	357691..357948	-	258	WP_000861987.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX87_RS14635	358214..358492	-	279	WP_001012254.1	hypothetical protein	-
GPX87_RS14640	358551..359402	-	852	WP_158116599.1	IS3 family transposase	-
GPX87_RS14645	359486..359707	-	222	Protein_344	transposase	-
GPX87_RS14650	359897..360664	-	768	WP_139364809.1	hypothetical protein	-
GPX87_RS14655	360706..361839	-	1134	WP_078927662.1	ISAs1 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	360706..361839	1133
	-	inside	Integron	-	-	352272..360664	8392

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11825.68 Da
• Isoelectric Point: 4.7473

>T144986 WP_078927641.1 NZ_CP046816:c357703-357401 [Vibrio cincinnatiensis]
MVEIIWTEPALSDLNDIAEYIELENAVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ

Nucleotide

• Length: 303 bp

>T144986 NZ_CP062248:c3161904-3161608 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9647.15 Da
• Isoelectric Point: 7.3178

>AT144986 WP_000861987.1 NZ_CP046816:c357948-357691 [Vibrio cincinnatiensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Nucleotide

• Length: 258 bp

>AT144986 NZ_CP062248:c3161606-3161211 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A1T4SLM9