Detailed information of TA system TA144981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 128776..129335
• Replicon: chromosome
• Accession: NZ_CP046812
• Organism: Vibrio alginolyticus strain 2010V-1102

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GPY28_RS00700
• Protein ID: WP_053307321.1
• Coordinates: 128776..129054 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2I3C6F3
• Locus tag: GPY28_RS00705
• Protein ID: WP_005487956.1
• Coordinates: 129051..129335 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY28_RS00645	123779..124717	+	939	WP_053307317.1	hypothetical protein	-
GPY28_RS00650	124857..125480	+	624	WP_053306419.1	hypothetical protein	-
GPY28_RS00655	125506..125598	+	93	WP_196334433.1	DUF3265 domain-containing protein	-
GPY28_RS24900	125801..126007	+	207	WP_053307318.1	hypothetical protein	-
GPY28_RS00665	126126..126218	+	93	WP_196334434.1	DUF3265 domain-containing protein	-
GPY28_RS00670	126560..126686	+	127	Protein_132	DUF3265 domain-containing protein	-
GPY28_RS00675	126712..127261	+	550	Protein_133	nucleotidyltransferase family protein	-
GPY28_RS00680	127396..127890	+	495	WP_053307319.1	hypothetical protein	-
GPY28_RS00685	127905..127997	+	93	WP_196334435.1	DUF3265 domain-containing protein	-
GPY28_RS00690	128100..128354	+	255	WP_017634119.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
GPY28_RS00695	128347..128616	+	270	WP_053307320.1	Txe/YoeB family addiction module toxin	-
GPY28_RS00700	128776..129054	-	279	WP_053307321.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GPY28_RS00705	129051..129335	-	285	WP_005487956.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GPY28_RS00710	129588..130022	+	435	WP_017634115.1	hypothetical protein	-
GPY28_RS00715	130137..130589	+	453	WP_017634114.1	GIY-YIG nuclease family protein	-
GPY28_RS00720	130815..131111	+	297	WP_053307322.1	YkgJ family cysteine cluster protein	-
GPY28_RS00725	131557..133119	-	1563	WP_053307374.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	116544..130022	13478

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10830.46 Da
• Isoelectric Point: 4.2397

>T144981 WP_053307321.1 NZ_CP046812:c129054-128776 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFIYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGVRGRLLIISEISMTVSYWIEGDVIRIM
SVLHQKQKFPMD

Nucleotide

• Length: 279 bp

>T144981 NZ_CP062248:c2083195-2082944 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11082.40 Da
• Isoelectric Point: 9.2167

>AT144981 WP_005487956.1 NZ_CP046812:c129335-129051 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQNAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT144981 NZ_CP062248:c2082947-2082693 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A2I3C6F3