Detailed information of TA system TA144980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 128100..128616
• Replicon: chromosome
• Accession: NZ_CP046812
• Organism: Vibrio alginolyticus strain 2010V-1102

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY28_RS00695
• Protein ID: WP_053307320.1
• Coordinates: 128347..128616 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0P7ESB6
• Locus tag: GPY28_RS00690
• Protein ID: WP_017634119.1
• Coordinates: 128100..128354 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY28_RS00640	123433..123564	+	132	WP_078535112.1	rubredoxin-like protein	-
GPY28_RS00645	123779..124717	+	939	WP_053307317.1	hypothetical protein	-
GPY28_RS00650	124857..125480	+	624	WP_053306419.1	hypothetical protein	-
GPY28_RS00655	125506..125598	+	93	WP_196334433.1	DUF3265 domain-containing protein	-
GPY28_RS24900	125801..126007	+	207	WP_053307318.1	hypothetical protein	-
GPY28_RS00665	126126..126218	+	93	WP_196334434.1	DUF3265 domain-containing protein	-
GPY28_RS00670	126560..126686	+	127	Protein_132	DUF3265 domain-containing protein	-
GPY28_RS00675	126712..127261	+	550	Protein_133	nucleotidyltransferase family protein	-
GPY28_RS00680	127396..127890	+	495	WP_053307319.1	hypothetical protein	-
GPY28_RS00685	127905..127997	+	93	WP_196334435.1	DUF3265 domain-containing protein	-
GPY28_RS00690	128100..128354	+	255	WP_017634119.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GPY28_RS00695	128347..128616	+	270	WP_053307320.1	Txe/YoeB family addiction module toxin	Toxin
GPY28_RS00700	128776..129054	-	279	WP_053307321.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
GPY28_RS00705	129051..129335	-	285	WP_005487956.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GPY28_RS00710	129588..130022	+	435	WP_017634115.1	hypothetical protein	-
GPY28_RS00715	130137..130589	+	453	WP_017634114.1	GIY-YIG nuclease family protein	-
GPY28_RS00720	130815..131111	+	297	WP_053307322.1	YkgJ family cysteine cluster protein	-
GPY28_RS00725	131557..133119	-	1563	WP_053307374.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	116544..130022	13478

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10618.95 Da
• Isoelectric Point: 7.9816

>T144980 WP_053307320.1 NZ_CP046812:128347-128616 [Vibrio alginolyticus]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSTFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T144980 NZ_CP046812:128347-128616 [Vibrio alginolyticus]
ATGAGTAGTAGTCAACGTTTACTGTCGTGGACTGATGACGCTTGGGATGACTACCTGTATTGGCAAACTCAAGACAAGAA
AACACTCAAGCGCATCAATAAACTCATCAATGATGTTAAACGCTCTACATTTGAGGGCATCGGCAAACCAGAGCCGTTAA
AAGAGAACTTATCTGGTTTTTGGTCTCGCCGTATTGATGACACTAATAGGCTTGTTTACGCAGTCGATGATCAAGCGATA
ACGATAATTTCGTGTCGTTACCACTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9455.57 Da
• Isoelectric Point: 4.7483

>AT144980 WP_017634119.1 NZ_CP046812:128100-128354 [Vibrio alginolyticus]
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTAQE
LIDE

Nucleotide

• Length: 255 bp

>AT144980 NZ_CP046812:128100-128354 [Vibrio alginolyticus]
ATGAGAATCGTATCTTTTACTGAAGCTAGAAATAGTCTTAAAGCTGTTTTAGACGGTGTAGTTAATGATGCTGATACAAC
AGTTATTACACGCCGTGATTCTGAAGATGCAGTGGTTATGTCTTTAGACTACTACAATAGCCTTATGGAGACAGTTCACT
TACTACGCTCTCCTCAAAACGCTGAACACCTAAATCGTTCGATTGCACAGTACCGTGCCGGTAAAACAACAGCACAAGAG
TTAATTGATGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0P7ESB6