Detailed information of TA system TA144974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 865961..866502
• Replicon: chromosome
• Accession: NZ_CP046810
• Organism: Grimontia hollisae strain 1078-81

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPY15_RS03985
• Protein ID: WP_114995249.1
• Coordinates: 865961..866260 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D0I9X4
• Locus tag: GPY15_RS03990
• Protein ID: WP_005505050.1
• Coordinates: 866257..866502 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY15_RS03950	861602..862563	-	962	Protein_756	integron integrase	-
GPY15_RS03955	862868..863110	+	243	WP_158161113.1	hypothetical protein	-
GPY15_RS03960	863502..864401	-	900	WP_158161115.1	IS110 family transposase	-
GPY15_RS03965	864493..864771	-	279	WP_005505046.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	-
GPY15_RS03970	864768..865052	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GPY15_RS03975	865128..865232	+	105	WP_192940932.1	DUF3265 domain-containing protein	-
GPY15_RS03980	865251..865685	+	435	WP_050778565.1	hypothetical protein	-
GPY15_RS03985	865961..866260	-	300	WP_114995249.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY15_RS03990	866257..866502	-	246	WP_005505050.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GPY15_RS03995	866659..867198	+	540	WP_005505051.1	isochorismatase family protein	-
GPY15_RS04000	867316..868749	-	1434	WP_158161117.1	amino acid permease	-
GPY15_RS04005	868827..869279	-	453	WP_005505055.1	beta-galactosidase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	vcrD2 / vcrD2 / vscU2 / VPA1353 / VPA1352 / VPA1351 / VPA1350 / vscQ2 / vscR2 / vscT2 / vscC2 / vscN2 / vscS2 / nueA	780088..1117455	337367
	-	flank	IS/Tn	-	-	863502..864401	899

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11721.45 Da
• Isoelectric Point: 9.9225

>T144974 WP_114995249.1 NZ_CP046810:c866260-865961 [Grimontia hollisae]
MKPFNLTVAAKTDLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFSQGSHVIFYLQTGRQQ
IRVIRILHKSMDVNPIFDA

Nucleotide

• Length: 300 bp

>T144974 NZ_CP062248:c1408184-1407990 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9197.00 Da
• Isoelectric Point: 4.1473

>AT144974 WP_005505050.1 NZ_CP046810:c866502-866257 [Grimontia hollisae]
MAKNTSITLGEHFDSFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLVEGEQSDDADYDIDSFVNELDSEENR
R

Nucleotide

• Length: 246 bp

>AT144974 NZ_CP062248:1407813-1407991 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin

• AlphaFold DB: A0A377HNW4