Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 864493..865052 Replicon chromosome
Accession NZ_CP046810
Organism Grimontia hollisae strain 1078-81

Toxin (Protein)


Gene name relE Uniprot ID D0I9X2
Locus tag GPY15_RS03965 Protein ID WP_005505046.1
Coordinates 864493..864771 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag GPY15_RS03970 Protein ID WP_005398409.1
Coordinates 864768..865052 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY15_RS03945 859922..861436 + 1515 WP_158161111.1 fumarate hydratase -
GPY15_RS03950 861602..862563 - 962 Protein_756 integron integrase -
GPY15_RS03955 862868..863110 + 243 WP_158161113.1 hypothetical protein -
GPY15_RS03960 863502..864401 - 900 WP_158161115.1 IS110 family transposase -
GPY15_RS03965 864493..864771 - 279 WP_005505046.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY15_RS03970 864768..865052 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY15_RS03975 865128..865232 + 105 WP_192940932.1 DUF3265 domain-containing protein -
GPY15_RS03980 865251..865685 + 435 WP_050778565.1 hypothetical protein -
GPY15_RS03985 865961..866260 - 300 WP_114995249.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY15_RS03990 866257..866502 - 246 WP_005505050.1 type II toxin-antitoxin system ParD family antitoxin -
GPY15_RS03995 866659..867198 + 540 WP_005505051.1 isochorismatase family protein -
GPY15_RS04000 867316..868749 - 1434 WP_158161117.1 amino acid permease -
GPY15_RS04005 868827..869279 - 453 WP_005505055.1 beta-galactosidase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vcrD2 / vcrD2 / vscU2 / VPA1353 / VPA1352 / VPA1351 / VPA1350 / vscQ2 / vscR2 / vscT2 / vscC2 / vscN2 / vscS2 / nueA 780088..1117455 337367
- flank IS/Tn - - 863502..864401 899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10910.62 Da        Isoelectric Point: 4.3430

>T144973 WP_005505046.1 NZ_CP046810:c864771-864493 [Grimontia hollisae]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDYLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPAD

Download         Length: 279 bp

>T144973 NZ_CP062248:c1265801-1265694 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT144973 WP_005398409.1 NZ_CP046810:c865052-864768 [Grimontia hollisae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT144973 NZ_CP062248:1265848-1265914 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377HNB0

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References