Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 633883..634430 Replicon chromosome
Accession NZ_CP046810
Organism Grimontia hollisae strain 1078-81

Toxin (Protein)


Gene name relE Uniprot ID D0I6P0
Locus tag GPY15_RS02935 Protein ID WP_005503214.1
Coordinates 634128..634430 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D0I6P1
Locus tag GPY15_RS02930 Protein ID WP_005503215.1
Coordinates 633883..634140 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY15_RS02930 633883..634140 + 258 WP_005503215.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY15_RS02935 634128..634430 + 303 WP_005503214.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY15_RS02940 635031..635453 + 423 WP_005503213.1 hypothetical protein -
GPY15_RS19045 635545..635778 + 234 WP_040528453.1 hypothetical protein -
GPY15_RS02950 635720..635884 + 165 Protein_566 IS6 family transposase -
GPY15_RS02955 636082..636906 + 825 Protein_567 2OG-Fe(II) oxygenase -
GPY15_RS02960 636911..637636 + 726 WP_005503206.1 hydrolase -
GPY15_RS02965 637645..638277 + 633 WP_005503205.1 LysE family translocator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 585616..636906 51290


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11654.57 Da        Isoelectric Point: 4.8950

>T144972 WP_005503214.1 NZ_CP046810:634128-634430 [Grimontia hollisae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTIFSKVERLESFPESGRIPPELEHLSCREVVVNPCRVFYKQDADKV
FILFVMRTERDLRKFLLSKQ

Download         Length: 303 bp

>T144972 NZ_CP062248:c1265266-1265159 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9678.21 Da        Isoelectric Point: 7.3182

>AT144972 WP_005503215.1 NZ_CP046810:633883-634140 [Grimontia hollisae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMRNRLSILEGIARGERALADGKVVSHEEAKDKM
SKWLK

Download         Length: 258 bp

>AT144972 NZ_CP062248:1265313-1265379 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377HQB7

Antitoxin

Source ID Structure
AlphaFold DB A0A377HP35

References