Detailed information of TA system TA144971

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2893038..2893597
• Replicon: chromosome
• Accession: NZ_CP046808
• Organism: Vibrio parahaemolyticus strain 2013V-1146

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A249W573
• Locus tag: GP469_RS14750
• Protein ID: WP_005500338.1
• Coordinates: 2893038..2893316 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: GP469_RS14755
• Protein ID: WP_005398409.1
• Coordinates: 2893313..2893597 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GP469_RS14690	2888108..2888200	+	93	WP_005500330.1	DUF3265 domain-containing protein	-
GP469_RS14695	2888226..2888663	+	438	WP_005500331.1	GIY-YIG nuclease family protein	-
GP469_RS14700	2889370..2889567	+	198	WP_005500332.1	hypothetical protein	-
GP469_RS14710	2890175..2890243	+	69	WP_079748735.1	DUF3265 domain-containing protein	-
GP469_RS14715	2890325..2890582	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GP469_RS14720	2890570..2890872	+	303	WP_005500333.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GP469_RS14725	2890911..2891000	+	90	WP_072828861.1	DUF3265 domain-containing protein	-
GP469_RS14730	2891048..2891416	+	369	WP_005500334.1	VOC family protein	-
GP469_RS14735	2891573..2892412	+	840	WP_005500335.1	hypothetical protein	-
GP469_RS14740	2892561..2892914	+	354	WP_005500336.1	glyoxalase/bleomycin resistance/dioxygenase family protein	-
GP469_RS25605	2892875..2893009	+	135	WP_161612893.1	DUF3265 domain-containing protein	-
GP469_RS14750	2893038..2893316	-	279	WP_005500338.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GP469_RS14755	2893313..2893597	-	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GP469_RS14760	2893864..2894154	+	291	WP_005500341.1	YkgJ family cysteine cluster protein	-
GP469_RS14765	2894822..2895972	+	1151	WP_088337786.1	IS3 family transposase	-
GP469_RS14770	2896004..2896375	+	372	Protein_2644	pyridoxamine 5'-phosphate oxidase family protein	-
GP469_RS14775	2896743..2897189	-	447	WP_005500348.1	DUF3291 domain-containing protein	-
GP469_RS14780	2897531..2897992	+	462	WP_005500350.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2791956..2897189	105233
	-	inside	Integron	-	-	2792480..2896508	104028

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10878.53 Da
• Isoelectric Point: 4.2597

>T144971 WP_005500338.1 NZ_CP046808:c2893316-2893038 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T144971 NZ_CP062248:c1264731-1264624 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT144971 WP_005398409.1 NZ_CP046808:c2893597-2893313 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT144971 NZ_CP062248:1264779-1264845 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A249W573

Antitoxin

• AlphaFold DB: A0A347UR21