Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2890325..2890872 Replicon chromosome
Accession NZ_CP046808
Organism Vibrio parahaemolyticus strain 2013V-1146

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5B6
Locus tag GP469_RS14720 Protein ID WP_005500333.1
Coordinates 2890570..2890872 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag GP469_RS14715 Protein ID WP_005448240.1
Coordinates 2890325..2890582 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP469_RS14640 2885654..2885746 + 93 WP_193268598.1 DUF3265 domain-containing protein -
GP469_RS14645 2885791..2886075 + 285 WP_005500325.1 nucleotide pyrophosphohydrolase -
GP469_RS14650 2886083..2886193 + 111 WP_082798391.1 DUF3265 domain-containing protein -
GP469_RS14655 2886220..2886492 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
GP469_RS14660 2886524..2886613 + 90 WP_079748734.1 DUF3265 domain-containing protein -
GP469_RS14665 2886644..2886940 + 297 WP_005500327.1 hypothetical protein -
GP469_RS14670 2886880..2887047 + 168 WP_086027883.1 DUF3265 domain-containing protein -
GP469_RS14675 2887077..2887457 + 381 WP_005487927.1 TonB family protein -
GP469_RS14680 2887464..2887574 + 111 WP_079861117.1 DUF3265 domain-containing protein -
GP469_RS14685 2887584..2888093 + 510 WP_005500328.1 hypothetical protein -
GP469_RS14690 2888108..2888200 + 93 WP_005500330.1 DUF3265 domain-containing protein -
GP469_RS14695 2888226..2888663 + 438 WP_005500331.1 GIY-YIG nuclease family protein -
GP469_RS14700 2889370..2889567 + 198 WP_005500332.1 hypothetical protein -
GP469_RS14710 2890175..2890243 + 69 WP_079748735.1 DUF3265 domain-containing protein -
GP469_RS14715 2890325..2890582 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GP469_RS14720 2890570..2890872 + 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GP469_RS14725 2890911..2891000 + 90 WP_072828861.1 DUF3265 domain-containing protein -
GP469_RS14730 2891048..2891416 + 369 WP_005500334.1 VOC family protein -
GP469_RS14735 2891573..2892412 + 840 WP_005500335.1 hypothetical protein -
GP469_RS14740 2892561..2892914 + 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
GP469_RS25605 2892875..2893009 + 135 WP_161612893.1 DUF3265 domain-containing protein -
GP469_RS14750 2893038..2893316 - 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GP469_RS14755 2893313..2893597 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GP469_RS14760 2893864..2894154 + 291 WP_005500341.1 YkgJ family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2791956..2897189 105233
- inside Integron - - 2792480..2896508 104028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.65 Da        Isoelectric Point: 6.9806

>T144970 WP_005500333.1 NZ_CP046808:2890570-2890872 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T144970 NZ_CP062248:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT144970 WP_005448240.1 NZ_CP046808:2890325-2890582 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT144970 NZ_CP062248:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5B6

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References