Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2839986..2840545 Replicon chromosome
Accession NZ_CP046808
Organism Vibrio parahaemolyticus strain 2013V-1146

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5L8
Locus tag GP469_RS14250 Protein ID WP_005497247.1
Coordinates 2839986..2840264 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2ZGZ5
Locus tag GP469_RS14255 Protein ID WP_005497249.1
Coordinates 2840261..2840545 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP469_RS14205 2835434..2835526 + 93 WP_079748755.1 DUF3265 domain-containing protein -
GP469_RS14210 2835573..2836007 + 435 WP_020838880.1 GNAT family N-acetyltransferase -
GP469_RS14215 2836162..2836518 + 357 WP_021485171.1 hypothetical protein -
GP469_RS14220 2836542..2836631 + 90 WP_079748782.1 DUF3265 domain-containing protein -
GP469_RS14225 2836668..2837177 + 510 WP_021447337.1 GNAT family N-acetyltransferase -
GP469_RS14230 2837192..2837283 + 92 Protein_2543 DUF3265 domain-containing protein -
GP469_RS14235 2837841..2838509 + 669 WP_005497242.1 GIY-YIG nuclease family protein -
GP469_RS14240 2839131..2839850 + 720 WP_021447410.1 hypothetical protein -
GP469_RS14245 2839865..2839957 + 93 WP_072036351.1 DUF3265 domain-containing protein -
GP469_RS14250 2839986..2840264 - 279 WP_005497247.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GP469_RS14255 2840261..2840545 - 285 WP_005497249.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GP469_RS14260 2840713..2841270 + 558 WP_005497250.1 nucleotidyltransferase domain-containing protein -
GP469_RS14265 2841456..2841815 + 360 WP_005497251.1 hypothetical protein -
GP469_RS14270 2842160..2842852 + 693 WP_127463323.1 hypothetical protein -
GP469_RS14275 2842959..2843372 + 414 WP_005500273.1 hypothetical protein -
GP469_RS14280 2843392..2843484 + 93 WP_069518749.1 DUF3265 domain-containing protein -
GP469_RS14285 2844105..2844308 + 204 WP_025793489.1 hypothetical protein -
GP469_RS14290 2844487..2844963 + 477 WP_005500215.1 GNAT family N-acetyltransferase -
GP469_RS14295 2844981..2845070 + 90 WP_079740873.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2791956..2897189 105233
- inside Integron - - 2792480..2896508 104028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10914.61 Da        Isoelectric Point: 4.4755

>T144969 WP_005497247.1 NZ_CP046808:c2840264-2839986 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDEVIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPVS

Download         Length: 279 bp

>T144969 NZ_CP062248:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10913.25 Da        Isoelectric Point: 9.1865

>AT144969 WP_005497249.1 NZ_CP046808:c2840545-2840261 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT144969 NZ_CP062248:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5L8

Antitoxin

Source ID Structure
AlphaFold DB U2ZGZ5

References