Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2813668..2814196 Replicon chromosome
Accession NZ_CP046808
Organism Vibrio parahaemolyticus strain 2013V-1146

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GP469_RS14020 Protein ID WP_005377002.1
Coordinates 2813668..2813958 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag GP469_RS14025 Protein ID WP_005377003.1
Coordinates 2813948..2814196 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GP469_RS13965 2809017..2809148 + 132 WP_005494795.1 DUF3265 domain-containing protein -
GP469_RS13970 2810159..2810281 + 123 WP_079748760.1 DUF3265 domain-containing protein -
GP469_RS13975 2810300..2810767 + 468 WP_005494803.1 GNAT family N-acetyltransferase -
GP469_RS13980 2810767..2810895 + 129 WP_161612914.1 DUF3265 domain-containing protein -
GP469_RS13985 2811259..2811351 + 93 WP_005494807.1 DUF3265 domain-containing protein -
GP469_RS13990 2811453..2811662 + 210 WP_025506672.1 DUF3955 domain-containing protein -
GP469_RS14000 2812336..2812425 + 90 WP_078235921.1 DUF3265 domain-containing protein -
GP469_RS14005 2812459..2812911 + 453 WP_005494814.1 hypothetical protein -
GP469_RS14010 2812947..2813039 + 93 WP_078535095.1 DUF3265 domain-containing protein -
GP469_RS14015 2813560..2813649 + 90 WP_077680412.1 DUF3265 domain-containing protein -
GP469_RS14020 2813668..2813958 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GP469_RS14025 2813948..2814196 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GP469_RS14030 2814944..2815348 + 405 WP_005494818.1 hypothetical protein -
GP469_RS14035 2815363..2815455 + 93 WP_005494820.1 DUF3265 domain-containing protein -
GP469_RS14045 2815945..2816076 + 132 WP_005494822.1 DUF3265 domain-containing protein -
GP469_RS14050 2816120..2816743 + 624 WP_005494825.1 hypothetical protein -
GP469_RS14055 2817368..2817889 + 522 WP_005494827.1 GNAT family N-acetyltransferase -
GP469_RS14060 2818496..2818882 + 387 WP_021447429.1 NUDIX hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2791956..2897189 105233
- inside Integron - - 2792480..2896508 104028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T144968 WP_005377002.1 NZ_CP046808:c2813958-2813668 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T144968 NZ_CP062248:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT144968 WP_005377003.1 NZ_CP046808:c2814196-2813948 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT144968 NZ_CP062248:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References