Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 68723..69489 Replicon plasmid unnamed1
Accession NZ_CP046807
Organism Vibrio alginolyticus strain 2439-01

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY47_RS23945 Protein ID WP_048626791.1
Coordinates 68723..69220 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY47_RS23950 Protein ID WP_048626792.1
Coordinates 69217..69489 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY47_RS23905 64127..65104 - 978 WP_048626786.1 hypothetical protein -
GPY47_RS23910 65097..65858 - 762 WP_048626787.1 hypothetical protein -
GPY47_RS23915 65861..66400 - 540 WP_048626788.1 hypothetical protein -
GPY47_RS23930 67139..67924 + 786 WP_048626789.1 NYN domain-containing protein -
GPY47_RS23935 67939..68032 + 94 Protein_64 DUF3265 domain-containing protein -
GPY47_RS23940 68064..68570 + 507 WP_048626790.1 AAA family ATPase -
GPY47_RS23945 68723..69220 - 498 WP_048626791.1 GNAT family N-acetyltransferase Toxin
GPY47_RS23950 69217..69489 - 273 WP_048626792.1 DUF1778 domain-containing protein Antitoxin
GPY47_RS23955 69741..70148 + 408 WP_158157505.1 OsmC family protein -
GPY47_RS23960 70163..70255 + 93 WP_193387730.1 DUF3265 domain-containing protein -
GPY47_RS23965 70597..71853 + 1257 WP_048626795.1 glucose-1-phosphate adenylyltransferase -
GPY47_RS23970 72450..73934 + 1485 WP_053084259.1 diguanylate cyclase -
GPY47_RS23975 74089..74336 + 248 Protein_72 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..142445 142445
- inside Integron - - 66688..70148 3460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18499.17 Da        Isoelectric Point: 8.8085

>T144966 WP_048626791.1 NZ_CP046807:c69220-68723 [Vibrio alginolyticus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHVIGFYTLTMTPIELKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADV
RASLG

Download         Length: 498 bp

>T144966 NZ_CP062247:c4570860-4570519 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9839.33 Da        Isoelectric Point: 6.3133

>AT144966 WP_048626792.1 NZ_CP046807:c69489-69217 [Vibrio alginolyticus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQAFKLSQADAMLLMEALDRPETQNSKLKA
AADRYESKIQ

Download         Length: 273 bp

>AT144966 NZ_CP062247:4570855-4570931 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References