Detailed information of TA system TA144965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 907986..908545
• Replicon: chromosome
• Accession: NZ_CP046806
• Organism: Vibrio alginolyticus strain 2439-01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A347UR22
• Locus tag: GPY47_RS12190
• Protein ID: WP_005398411.1
• Coordinates: 908267..908545 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY47_RS12185
• Protein ID: WP_158156595.1
• Coordinates: 907986..908270 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY47_RS12130	902996..903446	-	451	Protein_788	VOC family protein	-
GPY47_RS12135	903456..903548	-	93	WP_198556809.1	DUF3265 domain-containing protein	-
GPY47_RS12140	903576..904031	-	456	WP_053350294.1	hypothetical protein	-
GPY47_RS12145	904058..904150	-	93	WP_080256826.1	DUF3265 domain-containing protein	-
GPY47_RS12150	904165..904563	-	399	WP_025519062.1	hypothetical protein	-
GPY47_RS12155	904644..905183	-	540	WP_158156587.1	hypothetical protein	-
GPY47_RS12160	905778..906401	-	624	WP_080731377.1	HNH endonuclease	-
GPY47_RS12165	906540..906641	-	102	WP_158156589.1	DUF3265 domain-containing protein	-
GPY47_RS12170	906654..907121	-	468	WP_158156591.1	NUDIX domain-containing protein	-
GPY47_RS12175	907149..907241	-	93	WP_075111330.1	DUF3265 domain-containing protein	-
GPY47_RS12180	907256..907792	-	537	WP_199267704.1	nucleotidyltransferase family protein	-
GPY47_RS24420	907818..907909	-	92	Protein_799	DUF3265 domain-containing protein	-
GPY47_RS12185	907986..908270	+	285	WP_158156595.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GPY47_RS12190	908267..908545	+	279	WP_005398411.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GPY47_RS12195	908652..909188	-	537	WP_158156597.1	nucleotidyltransferase family protein	-
GPY47_RS24425	909214..909302	-	89	Protein_803	DUF3265 domain-containing protein	-
GPY47_RS12205	909320..909706	-	387	WP_158156599.1	ASCH domain-containing protein	-
GPY47_RS12210	910282..910374	-	93	WP_077672862.1	DUF3265 domain-containing protein	-
GPY47_RS12215	910395..911315	-	921	WP_104979401.1	toll/interleukin-1 receptor domain-containing protein	-
GPY47_RS12220	911371..911502	-	132	WP_010448870.1	DUF3265 domain-containing protein	-
GPY47_RS12225	911589..911870	+	282	WP_199267705.1	hypothetical protein	-
GPY47_RS12230	911992..912080	-	89	Protein_809	DUF3265 domain-containing protein	-
GPY47_RS12235	912109..912516	-	408	WP_017822010.1	hypothetical protein	-
GPY47_RS12240	912543..912635	-	93	WP_080284116.1	DUF3265 domain-containing protein	-
GPY47_RS12245	912674..913342	-	669	WP_158156603.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	888862..943595	54733
	-	inside	Integron	-	-	898656..942477	43821

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-74)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T144965 WP_005398411.1 NZ_CP046806:908267-908545 [Vibrio alginolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T144965 NZ_CP062247:c4525073-4524816 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11035.38 Da
• Isoelectric Point: 9.2167

>AT144965 WP_158156595.1 NZ_CP046806:907986-908270 [Vibrio alginolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKLDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT144965 NZ_CP062247:c4524804-4524259 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: A0A347UR22