Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1448056..1448584 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GPY24_RS13445 Protein ID WP_005377002.1
Coordinates 1448294..1448584 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag GPY24_RS13440 Protein ID WP_005377003.1
Coordinates 1448056..1448304 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY24_RS13390 1443209..1443301 - 93 WP_193784119.1 DUF3265 domain-containing protein -
GPY24_RS13395 1443328..1443769 - 442 Protein_1460 GNAT family N-acetyltransferase -
GPY24_RS13400 1443771..1443914 - 144 WP_156478495.1 DUF3265 domain-containing protein -
GPY24_RS13405 1443930..1445003 - 1074 WP_156478416.1 hypothetical protein -
GPY24_RS13410 1445591..1445716 - 126 WP_084834100.1 DUF3265 domain-containing protein -
GPY24_RS13415 1446044..1446166 - 123 WP_080960564.1 DUF3265 domain-containing protein -
GPY24_RS13420 1446163..1446729 - 567 WP_065818885.1 hypothetical protein -
GPY24_RS13425 1446882..1447340 - 459 WP_065818886.1 hypothetical protein -
GPY24_RS13430 1447352..1447492 - 141 WP_084834190.1 DUF3265 domain-containing protein -
GPY24_RS13435 1447476..1447856 - 381 WP_065818887.1 MmcQ/YjbR family DNA-binding protein -
GPY24_RS13440 1448056..1448304 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY24_RS13445 1448294..1448584 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY24_RS13450 1449075..1449185 - 111 WP_071908335.1 DUF3265 domain-containing protein -
GPY24_RS13455 1449844..1450281 - 438 WP_158118655.1 hypothetical protein -
GPY24_RS13460 1450330..1450455 - 126 WP_080284520.1 DUF3265 domain-containing protein -
GPY24_RS13470 1451266..1451376 - 111 WP_076008721.1 DUF3265 domain-containing protein -
GPY24_RS13475 1451736..1451954 - 219 WP_156478417.1 DUF3265 domain-containing protein -
GPY24_RS13480 1452189..1452311 - 123 Protein_1476 DUF3265 domain-containing protein -
GPY24_RS13485 1452308..1452733 - 426 WP_061897648.1 hypothetical protein -
GPY24_RS13490 1452963..1453415 - 453 WP_055032211.1 HPP family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1345123..1457587 112464
- inside Integron - - 1342300..1457749 115449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T144964 WP_005377002.1 NZ_CP046804:1448294-1448584 [Vibrio cidicii]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T144964 NZ_CP062247:4439712-4440062 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT144964 WP_005377003.1 NZ_CP046804:1448056-1448304 [Vibrio cidicii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT144964 NZ_CP062247:4439467-4439718 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References