Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1448056..1448584 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GPY24_RS13445 Protein ID WP_005377002.1
Coordinates 1448294..1448584 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag GPY24_RS13440 Protein ID WP_005377003.1
Coordinates 1448056..1448304 (+) Length 83 a.a.

Genomic Context

GPY24_RS13440GPY24_RS13445GPY24_RS13390GPY24_RS13395GPY24_RS13400GPY24_RS13405GPY24_RS13410GPY24_RS13415GPY24_RS13420GPY24_RS13425GPY24_RS13430GPY24_RS13435GPY24_RS13450GPY24_RS13455GPY24_RS13460GPY24_RS13470GPY24_RS13475GPY24_RS13480GPY24_RS13485GPY24_RS13490
Location: 1448056..1448304 (249 bp)
Type: Antitoxin
Protein ID: WP_005377003.1
Location: 1448294..1448584 (291 bp)
Type: Toxin
Protein ID: WP_005377002.1
Location: 1443209..1443301 (93 bp)
Type: Others
Protein ID: WP_193784119.1
Location: 1443328..1443769 (442 bp)
Type: Others
Protein ID: Protein_1460
Location: 1443771..1443914 (144 bp)
Type: Others
Protein ID: WP_156478495.1
Location: 1443930..1445003 (1074 bp)
Type: Others
Protein ID: WP_156478416.1
Location: 1445591..1445716 (126 bp)
Type: Others
Protein ID: WP_084834100.1
Location: 1446044..1446166 (123 bp)
Type: Others
Protein ID: WP_080960564.1
Location: 1446163..1446729 (567 bp)
Type: Others
Protein ID: WP_065818885.1
Location: 1446882..1447340 (459 bp)
Type: Others
Protein ID: WP_065818886.1
Location: 1447352..1447492 (141 bp)
Type: Others
Protein ID: WP_084834190.1
Location: 1447476..1447856 (381 bp)
Type: Others
Protein ID: WP_065818887.1
Location: 1449075..1449185 (111 bp)
Type: Others
Protein ID: WP_071908335.1
Location: 1449844..1450281 (438 bp)
Type: Others
Protein ID: WP_158118655.1
Location: 1450330..1450455 (126 bp)
Type: Others
Protein ID: WP_080284520.1
Location: 1451266..1451376 (111 bp)
Type: Others
Protein ID: WP_076008721.1
Location: 1451736..1451954 (219 bp)
Type: Others
Protein ID: WP_156478417.1
Location: 1452189..1452311 (123 bp)
Type: Others
Protein ID: Protein_1476
Location: 1452308..1452733 (426 bp)
Type: Others
Protein ID: WP_061897648.1
Location: 1452963..1453415 (453 bp)
Type: Others
Protein ID: WP_055032211.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY24_RS133901443209..1443301-93WP_193784119.1DUF3265 domain-containing protein-
GPY24_RS133951443328..1443769-442Protein_1460GNAT family N-acetyltransferase-
GPY24_RS134001443771..1443914-144WP_156478495.1DUF3265 domain-containing protein-
GPY24_RS134051443930..1445003-1074WP_156478416.1hypothetical protein-
GPY24_RS134101445591..1445716-126WP_084834100.1DUF3265 domain-containing protein-
GPY24_RS134151446044..1446166-123WP_080960564.1DUF3265 domain-containing protein-
GPY24_RS134201446163..1446729-567WP_065818885.1hypothetical protein-
GPY24_RS134251446882..1447340-459WP_065818886.1hypothetical protein-
GPY24_RS134301447352..1447492-141WP_084834190.1DUF3265 domain-containing protein-
GPY24_RS134351447476..1447856-381WP_065818887.1MmcQ/YjbR family DNA-binding protein-
GPY24_RS134401448056..1448304+249WP_005377003.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
GPY24_RS134451448294..1448584+291WP_005377002.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GPY24_RS134501449075..1449185-111WP_071908335.1DUF3265 domain-containing protein-
GPY24_RS134551449844..1450281-438WP_158118655.1hypothetical protein-
GPY24_RS134601450330..1450455-126WP_080284520.1DUF3265 domain-containing protein-
GPY24_RS134701451266..1451376-111WP_076008721.1DUF3265 domain-containing protein-
GPY24_RS134751451736..1451954-219WP_156478417.1DUF3265 domain-containing protein-
GPY24_RS134801452189..1452311-123Protein_1476DUF3265 domain-containing protein-
GPY24_RS134851452308..1452733-426WP_061897648.1hypothetical protein-
GPY24_RS134901452963..1453415-453WP_055032211.1HPP family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1345123..1457587112464
-insideIntegron--1342300..1457749115449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T144964 WP_005377002.1 NZ_CP046804:1448294-1448584 [Vibrio cidicii]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T144964 NZ_CP062247:4439712-4440062 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT144964 WP_005377003.1 NZ_CP046804:1448056-1448304 [Vibrio cidicii]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT144964 NZ_CP062247:4439467-4439718 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A347UR03

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A347UR02

References