Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1391466..1392004 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GPY24_RS12880 Protein ID WP_000802136.1
Coordinates 1391705..1392004 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GPY24_RS12875 Protein ID WP_001107719.1
Coordinates 1391466..1391708 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY24_RS12845 1387004..1387555 - 552 WP_158118650.1 hypothetical protein -
GPY24_RS12850 1387583..1387693 - 111 WP_084834184.1 DUF3265 domain-containing protein -
GPY24_RS12855 1388786..1389382 - 597 WP_065818840.1 hypothetical protein -
GPY24_RS12860 1389403..1389537 - 135 WP_197467441.1 DUF3265 domain-containing protein -
GPY24_RS12865 1390011..1390326 - 316 Protein_1360 DUF4144 domain-containing protein -
GPY24_RS12870 1390355..1390480 - 126 Protein_1361 DUF3265 domain-containing protein -
GPY24_RS12875 1391466..1391708 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPY24_RS12880 1391705..1392004 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY24_RS12885 1392121..1392657 - 537 WP_017046975.1 GNAT family N-acetyltransferase -
GPY24_RS12890 1392822..1393118 - 297 WP_065818842.1 Dabb family protein -
GPY24_RS12895 1393255..1393728 - 474 WP_065818843.1 HAD hydrolase-like protein -
GPY24_RS12900 1393774..1393833 - 60 WP_082798319.1 hypothetical protein -
GPY24_RS12905 1394222..1394347 - 126 WP_082796187.1 DUF3265 domain-containing protein -
GPY24_RS12910 1394690..1394815 - 126 WP_084834079.1 DUF3265 domain-containing protein -
GPY24_RS12920 1395747..1396061 - 315 WP_172462067.1 hypothetical protein -
GPY24_RS12925 1396195..1396482 - 288 WP_065818845.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1345123..1457587 112464
- inside Integron - - 1342300..1457749 115449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T144963 WP_000802136.1 NZ_CP046804:1391705-1392004 [Vibrio cidicii]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T144963 NZ_CP062247:4343928-4344101 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT144963 WP_001107719.1 NZ_CP046804:1391466-1391708 [Vibrio cidicii]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT144963 NZ_CP062247:4343604-4343900 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
PDB 7R5A
PDB 7B22
AlphaFold DB A0A151JFU4

References