Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1294183..1294681 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name - Uniprot ID A0A151JG87
Locus tag GPY24_RS12090 Protein ID WP_000589153.1
Coordinates 1294415..1294681 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A151JFU0
Locus tag GPY24_RS12085 Protein ID WP_000643599.1
Coordinates 1294183..1294428 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY24_RS12040 1289186..1289311 - 126 WP_082796158.1 DUF3265 domain-containing protein -
GPY24_RS12045 1289293..1289772 - 480 WP_065818787.1 GNAT family N-acetyltransferase -
GPY24_RS12050 1289917..1290873 - 957 WP_197467496.1 hypothetical protein -
GPY24_RS12055 1290930..1291463 - 534 WP_065818788.1 GNAT family N-acetyltransferase -
GPY24_RS12060 1291614..1292009 - 396 WP_000870857.1 DUF3465 domain-containing protein -
GPY24_RS12065 1292165..1293040 - 876 WP_065818789.1 hypothetical protein -
GPY24_RS12070 1293070..1293159 - 90 WP_084834173.1 DUF3265 domain-containing protein -
GPY24_RS12075 1293176..1293574 - 399 WP_156478402.1 hypothetical protein -
GPY24_RS12080 1293602..1293727 - 126 Protein_1209 DUF3265 domain-containing protein -
GPY24_RS12085 1294183..1294428 - 246 WP_000643599.1 hypothetical protein Antitoxin
GPY24_RS12090 1294415..1294681 - 267 WP_000589153.1 BrnT family toxin Toxin
GPY24_RS12095 1294858..1295322 - 465 WP_158118642.1 hypothetical protein -
GPY24_RS12100 1295440..1295733 - 294 WP_158118643.1 hypothetical protein -
GPY24_RS12105 1295721..1295813 - 93 WP_156478403.1 acetyltransferase -
GPY24_RS12110 1295870..1296145 - 276 WP_065819779.1 hypothetical protein -
GPY24_RS12115 1296185..1296334 - 150 WP_080478972.1 DUF3265 domain-containing protein -
GPY24_RS12120 1296292..1296576 - 285 Protein_1217 DUF2971 domain-containing protein -
GPY24_RS12125 1296696..1297397 - 702 WP_197467433.1 IS21-like element helper ATPase IstB -
GPY24_RS12130 1297408..1298940 - 1533 WP_065818814.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1287888..1315231 27343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10062.32 Da        Isoelectric Point: 7.3171

>T144962 WP_000589153.1 NZ_CP046804:c1294681-1294415 [Vibrio cidicii]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGANIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T144962 NZ_CP062247:c3694650-3694543 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9504.80 Da        Isoelectric Point: 6.2241

>AT144962 WP_000643599.1 NZ_CP046804:c1294428-1294183 [Vibrio cidicii]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMYKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT144962 NZ_CP062247:3694699-3694765 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151JG87

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU0

References