Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafQ-RelB |
| Location | 1254298..1254838 | Replicon | chromosome |
| Accession | NZ_CP046804 | ||
| Organism | Vibrio cidicii strain 2756-81 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A7Y3QIZ2 |
| Locus tag | GPY24_RS11775 | Protein ID | WP_039428600.1 |
| Coordinates | 1254569..1254838 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A1T4SKS5 |
| Locus tag | GPY24_RS11770 | Protein ID | WP_032480862.1 |
| Coordinates | 1254298..1254576 (+) | Length | 93 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY24_RS11725 | 1249514..1249639 | - | 126 | WP_081947101.1 | DUF3265 domain-containing protein | - |
| GPY24_RS11730 | 1250103..1250564 | - | 462 | WP_065818763.1 | hypothetical protein | - |
| GPY24_RS11735 | 1250573..1250719 | - | 147 | WP_084834170.1 | DUF3265 domain-containing protein | - |
| GPY24_RS11740 | 1250729..1250950 | - | 222 | WP_017420735.1 | VF530 family protein | - |
| GPY24_RS11745 | 1251110..1251169 | - | 60 | WP_156478487.1 | DUF3265 domain-containing protein | - |
| GPY24_RS11755 | 1252900..1253043 | - | 144 | WP_156478488.1 | DUF3265 domain-containing protein | - |
| GPY24_RS11760 | 1253025..1253504 | - | 480 | WP_065818765.1 | GNAT family N-acetyltransferase | - |
| GPY24_RS11765 | 1253648..1254103 | - | 456 | WP_197467483.1 | GNAT family N-acetyltransferase | - |
| GPY24_RS11770 | 1254298..1254576 | + | 279 | WP_032480862.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GPY24_RS11775 | 1254569..1254838 | + | 270 | WP_039428600.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
| GPY24_RS11780 | 1255332..1255457 | - | 126 | WP_156478397.1 | DUF3265 domain-containing protein | - |
| GPY24_RS11785 | 1255466..1255837 | - | 372 | WP_033935939.1 | DUF4440 domain-containing protein | - |
| GPY24_RS11790 | 1256453..1256887 | - | 435 | WP_065818767.1 | GNAT family N-acetyltransferase | - |
| GPY24_RS11795 | 1256878..1257042 | - | 165 | WP_084834042.1 | DUF3265 domain-containing protein | - |
| GPY24_RS11800 | 1257026..1257340 | - | 315 | WP_065818768.1 | hypothetical protein | - |
| GPY24_RS11805 | 1258601..1259068 | - | 468 | WP_167520846.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 1214463..1284432 | 69969 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10250.91 Da Isoelectric Point: 8.9357
>T144961 WP_039428600.1 NZ_CP046804:1254569-1254838 [Vibrio cidicii]
MYSLEYSTQFKKDFKKITKMPISDIIEVGNIISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDGQLQLA
RIGSHSDLF
MYSLEYSTQFKKDFKKITKMPISDIIEVGNIISKLQRGEKLDPKNVDHPLTGGWVGFRDCHVKPDLVLIYRIFDGQLQLA
RIGSHSDLF
Download Length: 270 bp
>T144961 NZ_CP062247:3271899-3272363 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10053.51 Da Isoelectric Point: 6.0643
>AT144961 WP_032480862.1 NZ_CP046804:1254298-1254576 [Vibrio cidicii]
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVDAM
LTELTEGKVKNV
MRTEMLSTRIDHDTKVAFTSICDEMGLSTSQAIKIFAKAVINHGGIPFDLRVPQPNETTISAMNELVQGHGHKAESVDAM
LTELTEGKVKNV
Download Length: 279 bp
>AT144961 NZ_CP062247:3271564-3271899 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y3QIZ2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SKS5 |