Detailed information of TA system TA144959

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1200554..1201082
• Replicon: chromosome
• Accession: NZ_CP046804
• Organism: Vibrio cidicii strain 2756-81

Toxin (Protein)

• Gene name: relE
• Uniprot ID: W9UY41
• Locus tag: GPY24_RS11265
• Protein ID: WP_000221356.1
• Coordinates: 1200554..1200841 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: W9V7T8
• Locus tag: GPY24_RS11270
• Protein ID: WP_001250181.1
• Coordinates: 1200831..1201082 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY24_RS11220	1196492..1196602	-	111	WP_084834164.1	DUF3265 domain-containing protein	-
GPY24_RS11225	1197077..1197829	-	753	WP_065818738.1	SDR family oxidoreductase	-
GPY24_RS22795	1198331..1198402	-	72	WP_167520860.1	hypothetical protein	-
GPY24_RS11235	1198450..1198797	-	348	WP_158118631.1	ASCH domain-containing protein	-
GPY24_RS11245	1199033..1199215	-	183	WP_019829944.1	DUF645 family protein	-
GPY24_RS22800	1199384..1199455	-	72	WP_114983889.1	hypothetical protein	-
GPY24_RS11255	1199975..1200412	-	438	WP_061058665.1	GNAT family N-acetyltransferase	-
GPY24_RS11265	1200554..1200841	-	288	WP_000221356.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY24_RS11270	1200831..1201082	-	252	WP_001250181.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY24_RS11275	1201142..1201291	-	150	WP_197467480.1	DUF3265 domain-containing protein	-
GPY24_RS11280	1201287..1201703	-	417	WP_158118632.1	hypothetical protein	-
GPY24_RS11285	1202307..1202729	-	423	WP_017188767.1	hypothetical protein	-
GPY24_RS11290	1202729..1202869	-	141	WP_084834026.1	DUF3265 domain-containing protein	-
GPY24_RS11305	1203398..1203436	-	39	WP_113629368.1	hypothetical protein	-
GPY24_RS11310	1203452..1203577	-	126	WP_084834028.1	DUF645 family protein	-
GPY24_RS11315	1204159..1205853	-	1695	WP_065818741.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1179870..1203343	23473

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (11-62)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11054.97 Da
• Isoelectric Point: 10.5827

>T144959 WP_000221356.1 NZ_CP046804:c1200841-1200554 [Vibrio cidicii]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSSKLRGYDSVYKIKLRTSGYRLAYEVIDNEVVVYVLAVGK
RDKDAVYKKLASRFS

Nucleotide

• Length: 288 bp

>T144959 NZ_CP062247:c3163106-3162810 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9170.32 Da
• Isoelectric Point: 4.0197

>AT144959 WP_001250181.1 NZ_CP046804:c1201082-1200831 [Vibrio cidicii]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLMDMLDDYELSQIVDSRRGDLSQAVEINI
DDL

Nucleotide

• Length: 252 bp

>AT144959 NZ_CP062247:c3162808-3162413 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• AlphaFold DB: W9UY41

Antitoxin

• AlphaFold DB: W9V7T8