Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1192110..1193041 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY24_RS11175 Protein ID WP_158118630.1
Coordinates 1192110..1192643 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY24_RS11180 Protein ID WP_084834023.1
Coordinates 1192640..1193041 (-) Length 134 a.a.

Genomic Context

GPY24_RS11140GPY24_RS11200GPY24_RS11205GPY24_RS11135GPY24_RS11145GPY24_RS11150GPY24_RS11155GPY24_RS11160GPY24_RS11165GPY24_RS11175GPY24_RS11180GPY24_RS11185GPY24_RS11190GPY24_RS11210GPY24_RS11215GPY24_RS11220GPY24_RS11225
Location: 1188598..1188834 (237 bp)
Type: Others
Protein ID: WP_065818732.1
Location: 1194793..1195077 (285 bp)
Type: Others
Protein ID: WP_000381185.1
Location: 1195074..1195352 (279 bp)
Type: Others
Protein ID: WP_065818737.1
Location: 1187176..1188315 (1140 bp)
Type: Others
Protein ID: WP_065818731.1
Location: 1189009..1189695 (687 bp)
Type: Others
Protein ID: Protein_1040
Location: 1189670..1190005 (336 bp)
Type: Others
Protein ID: WP_065818733.1
Location: 1190503..1190592 (90 bp)
Type: Others
Protein ID: WP_081946668.1
Location: 1190636..1190941 (306 bp)
Type: Others
Protein ID: Protein_1043
Location: 1191062..1191934 (873 bp)
Type: Others
Protein ID: WP_065818734.1
Location: 1192110..1192643 (534 bp)
Type: Toxin
Protein ID: WP_158118630.1
Location: 1192640..1193041 (402 bp)
Type: Antitoxin
Protein ID: WP_084834023.1
Location: 1193134..1193667 (534 bp)
Type: Others
Protein ID: WP_065818735.1
Location: 1193699..1193824 (126 bp)
Type: Others
Protein ID: WP_080532886.1
Location: 1195371..1195493 (123 bp)
Type: Others
Protein ID: Protein_1051
Location: 1195490..1195848 (359 bp)
Type: Others
Protein ID: Protein_1052
Location: 1196492..1196602 (111 bp)
Type: Others
Protein ID: WP_084834164.1
Location: 1197077..1197829 (753 bp)
Type: Others
Protein ID: WP_065818738.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY24_RS111351187176..1188315-1140WP_065818731.1ISAs1 family transposase-
GPY24_RS111401188598..1188834+237WP_065818732.1RNA-binding protein-
GPY24_RS111451189009..1189695-687Protein_1040aminoglycoside phosphotransferase family protein-
GPY24_RS111501189670..1190005-336WP_065818733.1hypothetical protein-
GPY24_RS111551190503..1190592-90WP_081946668.1DUF3265 domain-containing protein-
GPY24_RS111601190636..1190941-306Protein_1043DUF4144 domain-containing protein-
GPY24_RS111651191062..1191934-873WP_065818734.1hypothetical protein-
GPY24_RS111751192110..1192643-534WP_158118630.1GNAT family N-acetyltransferaseToxin
GPY24_RS111801192640..1193041-402WP_084834023.1DUF1778 domain-containing proteinAntitoxin
GPY24_RS111851193134..1193667-534WP_065818735.1cysteine hydrolase-
GPY24_RS111901193699..1193824-126WP_080532886.1DUF3265 domain-containing protein-
GPY24_RS112001194793..1195077+285WP_000381185.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
GPY24_RS112051195074..1195352+279WP_065818737.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
GPY24_RS112101195371..1195493-123Protein_1051DUF3265 domain-containing protein-
GPY24_RS112151195490..1195848-359Protein_1052VOC family protein-
GPY24_RS112201196492..1196602-111WP_084834164.1DUF3265 domain-containing protein-
GPY24_RS112251197077..1197829-753WP_065818738.1SDR family oxidoreductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--1187176..11883151139
-insideIntegron--1179870..120334323473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(49-125)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20199.52 Da        Isoelectric Point: 9.1432

>T144957 WP_158118630.1 NZ_CP046804:c1192643-1192110 [Vibrio cidicii]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRVYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T144957 NZ_CP062247:c2905653-2905318 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14664.97 Da        Isoelectric Point: 6.4700

>AT144957 WP_084834023.1 NZ_CP046804:c1193041-1192640 [Vibrio cidicii]
VPASLLNRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 402 bp

>AT144957 NZ_CP062247:c2905901-2905653 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
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Antitoxin

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Source
ID
Structure
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References