Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 1192110..1193041 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY24_RS11175 Protein ID WP_158118630.1
Coordinates 1192110..1192643 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GPY24_RS11180 Protein ID WP_084834023.1
Coordinates 1192640..1193041 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY24_RS11135 1187176..1188315 - 1140 WP_065818731.1 ISAs1 family transposase -
GPY24_RS11140 1188598..1188834 + 237 WP_065818732.1 RNA-binding protein -
GPY24_RS11145 1189009..1189695 - 687 Protein_1040 aminoglycoside phosphotransferase family protein -
GPY24_RS11150 1189670..1190005 - 336 WP_065818733.1 hypothetical protein -
GPY24_RS11155 1190503..1190592 - 90 WP_081946668.1 DUF3265 domain-containing protein -
GPY24_RS11160 1190636..1190941 - 306 Protein_1043 DUF4144 domain-containing protein -
GPY24_RS11165 1191062..1191934 - 873 WP_065818734.1 hypothetical protein -
GPY24_RS11175 1192110..1192643 - 534 WP_158118630.1 GNAT family N-acetyltransferase Toxin
GPY24_RS11180 1192640..1193041 - 402 WP_084834023.1 DUF1778 domain-containing protein Antitoxin
GPY24_RS11185 1193134..1193667 - 534 WP_065818735.1 cysteine hydrolase -
GPY24_RS11190 1193699..1193824 - 126 WP_080532886.1 DUF3265 domain-containing protein -
GPY24_RS11200 1194793..1195077 + 285 WP_000381185.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY24_RS11205 1195074..1195352 + 279 WP_065818737.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY24_RS11210 1195371..1195493 - 123 Protein_1051 DUF3265 domain-containing protein -
GPY24_RS11215 1195490..1195848 - 359 Protein_1052 VOC family protein -
GPY24_RS11220 1196492..1196602 - 111 WP_084834164.1 DUF3265 domain-containing protein -
GPY24_RS11225 1197077..1197829 - 753 WP_065818738.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1187176..1188315 1139
- inside Integron - - 1179870..1203343 23473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(49-125)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 20199.52 Da        Isoelectric Point: 9.1432

>T144957 WP_158118630.1 NZ_CP046804:c1192643-1192110 [Vibrio cidicii]
VSWGKEFVELSKSKHDRDSFDCGEQELNTFIKTQAAKHMQAGISRTMVLPSAHPLLNQKFAICAFYSVAPSSISRETLPA
QLAKKLPRYPIPVFLLAQLAVHKEFHGSGLGKVSLIRALKYLWEVNHHMRVYAIVVDCLTDSAQAFYTKFGFEVLCEHNE
RIRMFLPMKTVEQLFNQ

Download         Length: 534 bp

>T144957 NZ_CP062247:c2905653-2905318 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14664.97 Da        Isoelectric Point: 6.4700

>AT144957 WP_084834023.1 NZ_CP046804:c1193041-1192640 [Vibrio cidicii]
VPASLLNRALYSPSPRKLSVRIECALSLAYNRSTDGMYPYAGGVMATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVR
LMDEDATHVIEEHESIMVKDSVFDEFMAACNKVKAPNQALLEAVKFTEKSGIK

Download         Length: 402 bp

>AT144957 NZ_CP062247:c2905901-2905653 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References