Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 1171107..1171678 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag GPY24_RS10980 Protein ID WP_000351248.1
Coordinates 1171107..1171508 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag GPY24_RS10985 Protein ID WP_001080654.1
Coordinates 1171508..1171678 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY24_RS10950 1166754..1167488 + 735 WP_065818716.1 transporter substrate-binding domain-containing protein -
GPY24_RS10955 1167527..1168795 + 1269 WP_158118627.1 HD domain-containing protein -
GPY24_RS10960 1168792..1169718 - 927 WP_061898576.1 EamA family transporter -
GPY24_RS10965 1169992..1170399 + 408 WP_061898575.1 nucleoside diphosphate kinase regulator -
GPY24_RS10970 1170579..1170962 - 384 WP_158118628.1 GNAT family N-acetyltransferase -
GPY24_RS10975 1170994..1171137 - 144 WP_071908341.1 DUF3265 domain-containing protein -
GPY24_RS10980 1171107..1171508 - 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GPY24_RS10985 1171508..1171678 - 171 WP_001080654.1 hypothetical protein Antitoxin
GPY24_RS10990 1171749..1171838 - 90 WP_084834159.1 DUF3265 domain-containing protein -
GPY24_RS10995 1171867..1172322 - 456 WP_061900879.1 GNAT family N-acetyltransferase -
GPY24_RS11000 1172341..1172463 - 123 WP_084834160.1 DUF3265 domain-containing protein -
GPY24_RS11005 1172460..1172904 - 445 Protein_1013 GNAT family N-acetyltransferase -
GPY24_RS11010 1172945..1173070 - 126 WP_080532886.1 DUF3265 domain-containing protein -
GPY24_RS11015 1173413..1173538 - 126 WP_084834016.1 DUF3265 domain-containing protein -
GPY24_RS11020 1173870..1173992 - 123 Protein_1016 DUF3265 domain-containing protein -
GPY24_RS11025 1173989..1174414 - 426 WP_065818721.1 hypothetical protein -
GPY24_RS11030 1174526..1174642 - 117 WP_197467431.1 DUF3265 domain-containing protein -
GPY24_RS11035 1174639..1175014 - 376 Protein_1019 hypothetical protein -
GPY24_RS11040 1175042..1175131 - 90 WP_081048319.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 1170579..1174414 3835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T144956 WP_000351248.1 NZ_CP046804:c1171508-1171107 [Vibrio cidicii]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T144956 NZ_CP062247:2772015-2772344 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT144956 WP_001080654.1 NZ_CP046804:c1171678-1171508 [Vibrio cidicii]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT144956 NZ_CP062247:2771677-2771994 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References