Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 123851..125676 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPY24_RS06320 Protein ID WP_167520843.1
Coordinates 124315..125676 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A151JL79
Locus tag GPY24_RS06315 Protein ID WP_061899664.1
Coordinates 123851..124318 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY24_RS06285 119121..119711 - 591 WP_065819828.1 DedA family protein -
GPY24_RS06290 120011..120973 - 963 WP_065819492.1 threonylcarbamoyl-AMP synthase -
GPY24_RS06295 121247..121471 + 225 WP_039434078.1 hypothetical protein -
GPY24_RS06300 121527..122006 - 480 WP_065819493.1 MarR family transcriptional regulator -
GPY24_RS06305 122128..123027 + 900 WP_158118523.1 EamA family transporter -
GPY24_RS06310 123029..123622 + 594 WP_061898230.1 NAD(P)H-dependent oxidoreductase -
GPY24_RS06315 123851..124318 - 468 WP_061899664.1 helix-turn-helix domain-containing protein Antitoxin
GPY24_RS06320 124315..125676 - 1362 WP_167520843.1 type II toxin-antitoxin system HipA family toxin Toxin
GPY24_RS06330 126527..127012 - 486 WP_039424337.1 SsrA-binding protein SmpB -
GPY24_RS06335 127128..127559 + 432 WP_039424339.1 ubiquinone-binding protein -
GPY24_RS06340 127556..127852 + 297 WP_065819494.1 RnfH family protein -
GPY24_RS06345 127969..128329 - 361 Protein_109 outer membrane protein assembly factor BamE -
GPY24_RS06350 128501..130166 - 1666 Protein_110 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51207.14 Da        Isoelectric Point: 5.0436

>T144955 WP_167520843.1 NZ_CP046804:c125676-124315 [Vibrio cidicii]
MEALTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLGDYALEHHDKDDFHAVSLNHPISFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T144955 NZ_CP062247:2760480-2761553 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17159.59 Da        Isoelectric Point: 10.7497

>AT144955 WP_061899664.1 NZ_CP046804:c124318-123851 [Vibrio cidicii]
MKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVNVSRKTLSDIENDRGSYNTEILNKVFKLFGLKVGLLPSSPDALKSLLIDDEAE

Download         Length: 468 bp

>AT144955 NZ_CP062247:2761546-2761917 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A151JL79

References