Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 123851..125676 Replicon chromosome
Accession NZ_CP046804
Organism Vibrio cidicii strain 2756-81

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GPY24_RS06320 Protein ID WP_167520843.1
Coordinates 124315..125676 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A151JL79
Locus tag GPY24_RS06315 Protein ID WP_061899664.1
Coordinates 123851..124318 (-) Length 156 a.a.

Genomic Context

GPY24_RS06295GPY24_RS06305GPY24_RS06310GPY24_RS06335GPY24_RS06340GPY24_RS06285GPY24_RS06290GPY24_RS06300GPY24_RS06315GPY24_RS06320GPY24_RS06330GPY24_RS06345GPY24_RS06350
Location: 121247..121471 (225 bp)
Type: Others
Protein ID: WP_039434078.1
Location: 122128..123027 (900 bp)
Type: Others
Protein ID: WP_158118523.1
Location: 123029..123622 (594 bp)
Type: Others
Protein ID: WP_061898230.1
Location: 127128..127559 (432 bp)
Type: Others
Protein ID: WP_039424339.1
Location: 127556..127852 (297 bp)
Type: Others
Protein ID: WP_065819494.1
Location: 119121..119711 (591 bp)
Type: Others
Protein ID: WP_065819828.1
Location: 120011..120973 (963 bp)
Type: Others
Protein ID: WP_065819492.1
Location: 121527..122006 (480 bp)
Type: Others
Protein ID: WP_065819493.1
Location: 123851..124318 (468 bp)
Type: Antitoxin
Protein ID: WP_061899664.1
Location: 124315..125676 (1362 bp)
Type: Toxin
Protein ID: WP_167520843.1
Location: 126527..127012 (486 bp)
Type: Others
Protein ID: WP_039424337.1
Location: 127969..128329 (361 bp)
Type: Others
Protein ID: Protein_109
Location: 128501..130166 (1666 bp)
Type: Others
Protein ID: Protein_110
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GPY24_RS06285119121..119711-591WP_065819828.1DedA family protein-
GPY24_RS06290120011..120973-963WP_065819492.1threonylcarbamoyl-AMP synthase-
GPY24_RS06295121247..121471+225WP_039434078.1hypothetical protein-
GPY24_RS06300121527..122006-480WP_065819493.1MarR family transcriptional regulator-
GPY24_RS06305122128..123027+900WP_158118523.1EamA family transporter-
GPY24_RS06310123029..123622+594WP_061898230.1NAD(P)H-dependent oxidoreductase-
GPY24_RS06315123851..124318-468WP_061899664.1helix-turn-helix domain-containing proteinAntitoxin
GPY24_RS06320124315..125676-1362WP_167520843.1type II toxin-antitoxin system HipA family toxinToxin
GPY24_RS06330126527..127012-486WP_039424337.1SsrA-binding protein SmpB-
GPY24_RS06335127128..127559+432WP_039424339.1ubiquinone-binding protein-
GPY24_RS06340127556..127852+297WP_065819494.1RnfH family protein-
GPY24_RS06345127969..128329-361Protein_109outer membrane protein assembly factor BamE-
GPY24_RS06350128501..130166-1666Protein_110DNA repair protein RecN-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-383)

Antitoxin

Cro/C1-type helix-turn-helix domain

(80-138)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51207.14 Da        Isoelectric Point: 5.0436

>T144955 WP_167520843.1 NZ_CP046804:c125676-124315 [Vibrio cidicii]
MEALTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLGDYALEHHDKDDFHAVSLNHPISFFFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSNHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T144955 NZ_CP062247:2760480-2761553 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17159.59 Da        Isoelectric Point: 10.7497

>AT144955 WP_061899664.1 NZ_CP046804:c124318-123851 [Vibrio cidicii]
MKPSNKESVQDTVARLRANRNQHQPKTGTDATHSTKERSQLNTPTRSKTSKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVNVSRKTLSDIENDRGSYNTEILNKVFKLFGLKVGLLPSSPDALKSLLIDDEAE

Download         Length: 468 bp

>AT144955 NZ_CP062247:2761546-2761917 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A151JL79

References