Detailed information of TA system TA144953

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 489279..489829
• Replicon: chromosome
• Accession: NZ_CP046801
• Organism: Vibrio cincinnatiensis strain 2070-81

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1T4SPA2
• Locus tag: GPX92_RS02165
• Protein ID: WP_039428516.1
• Coordinates: 489279..489578 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A099LYH9
• Locus tag: GPX92_RS02170
• Protein ID: WP_039428513.1
• Coordinates: 489587..489829 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX92_RS02130	484606..485403	-	798	WP_158116598.1	enhanced serine sensitivity protein SseB	-
GPX92_RS02135	485453..486304	-	852	WP_158116599.1	IS3 family transposase	-
GPX92_RS02140	486388..486609	-	222	Protein_425	transposase	-
GPX92_RS02145	486800..486910	+	111	WP_072668972.1	DUF3265 domain-containing protein	-
GPX92_RS02150	486995..487327	+	333	WP_158116600.1	hypothetical protein	-
GPX92_RS02155	487314..487769	+	456	WP_158116601.1	hypothetical protein	-
GPX92_RS02160	488287..489147	+	861	WP_158116602.1	hypothetical protein	-
GPX92_RS02165	489279..489578	-	300	WP_039428516.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX92_RS02170	489587..489829	-	243	WP_039428513.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX92_RS02175	489940..490035	+	96	Protein_432	DUF3265 domain-containing protein	-
GPX92_RS02180	490083..490508	+	426	WP_032471965.1	N-acetyltransferase	-
GPX92_RS02185	490651..491205	+	555	WP_158116603.1	hypothetical protein	-
GPX92_RS02190	491341..492093	+	753	WP_158116604.1	hypothetical protein	-
GPX92_RS02195	492294..492515	+	222	Protein_436	transposase	-
GPX92_RS02200	492599..493450	+	852	WP_158116599.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	486995..502887	15892
	-	inside	Integron	-	-	460999..484479	23480
	-	inside	Integron	-	-	486301..492602	6301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-56)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11622.26 Da
• Isoelectric Point: 9.6429

>T144953 WP_039428516.1 NZ_CP046801:c489578-489279 [Vibrio cincinnatiensis]
MHNKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T144953 NZ_CP062247:c2084149-2083895 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9164.51 Da
• Isoelectric Point: 5.6772

>AT144953 WP_039428513.1 NZ_CP046801:c489829-489587 [Vibrio cincinnatiensis]
MYTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKHCFNVAKDDLAKGNVVDGKDFLNEL

Nucleotide

• Length: 243 bp

>AT144953 NZ_CP062247:c2084397-2084146 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Structures

Toxin

• AlphaFold DB: A0A1T4SPA2

Antitoxin

• AlphaFold DB: A0A099LYH9