Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 463967..464514 Replicon chromosome
Accession NZ_CP046801
Organism Vibrio cincinnatiensis strain 2070-81

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GPX92_RS02005 Protein ID WP_078927641.1
Coordinates 463967..464269 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag GPX92_RS02010 Protein ID WP_000861987.1
Coordinates 464257..464514 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX92_RS01980 459551..460580 - 1030 Protein_393 IS630 family transposase -
GPX92_RS01985 461012..461122 - 111 WP_158116794.1 DUF3265 domain-containing protein -
GPX92_RS01990 461763..462050 - 288 WP_158116587.1 antibiotic biosynthesis monooxygenase -
GPX92_RS01995 462112..462225 - 114 WP_158116795.1 DUF3265 domain-containing protein -
GPX92_RS02000 462443..463525 - 1083 Protein_397 IS3 family transposase -
GPX92_RS02005 463967..464269 - 303 WP_078927641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPX92_RS02010 464257..464514 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPX92_RS02015 465312..466445 - 1134 WP_158116588.1 ISAs1 family transposase -
GPX92_RS02020 466680..468005 - 1326 WP_115173883.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 453568..466445 12877
- inside Integron - - 460999..484479 23480


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11825.68 Da        Isoelectric Point: 4.7473

>T144951 WP_078927641.1 NZ_CP046801:c464269-463967 [Vibrio cincinnatiensis]
MVEIIWTEPALSDLNDIAEYIELENAVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDEKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T144951 NZ_CP062247:c1918667-1918564 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT144951 WP_000861987.1 NZ_CP046801:c464514-464257 [Vibrio cincinnatiensis]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT144951 NZ_CP062247:1918526-1918797 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References