Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 159180..159690 Replicon chromosome
Accession NZ_CP046794
Organism Vibrio metschnikovii strain 9502-00

Toxin (Protein)


Gene name relB Uniprot ID A0A7X5B740
Locus tag GPX86_RS13970 Protein ID WP_010318499.1
Coordinates 159180..159443 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7X5B7D9
Locus tag GPX86_RS13975 Protein ID WP_009836585.1
Coordinates 159436..159690 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPX86_RS13945 154586..156373 - 1788 WP_158145102.1 AIPR family protein -
GPX86_RS13950 157295..157705 - 411 WP_000443644.1 cytidine deaminase -
GPX86_RS13955 157746..157862 - 117 WP_158145103.1 DUF3265 domain-containing protein -
GPX86_RS13960 157872..158330 - 459 WP_158145104.1 DUF2127 domain-containing protein -
GPX86_RS13965 159048..159143 - 96 Protein_161 DUF3265 domain-containing protein -
GPX86_RS13970 159180..159443 - 264 WP_010318499.1 Txe/YoeB family addiction module toxin Toxin
GPX86_RS13975 159436..159690 - 255 WP_009836585.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GPX86_RS13980 159790..159906 - 117 WP_158145103.1 DUF3265 domain-containing protein -
GPX86_RS13985 159916..160374 - 459 WP_158145105.1 DUF2127 domain-containing protein -
GPX86_RS13990 160402..160512 - 111 WP_081480741.1 DUF3265 domain-containing protein -
GPX86_RS13995 161200..161610 - 411 WP_000152776.1 GNAT family N-acetyltransferase -
GPX86_RS14000 161914..162876 + 963 WP_158145106.1 integron integrase -
GPX86_RS14005 162924..163277 - 354 WP_004397165.1 50S ribosomal protein L20 -
GPX86_RS14010 163319..163513 - 195 WP_004397162.1 50S ribosomal protein L35 -
GPX86_RS14015 163614..164165 - 552 WP_083797783.1 translation initiation factor IF-3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 122740..164003 41263
- inside Integron - - 131709..162876 31167


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10360.71 Da        Isoelectric Point: 8.8578

>T144949 WP_010318499.1 NZ_CP046794:c159443-159180 [Vibrio metschnikovii]
MSSRLLSWTDESWNDYVYWQTQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDSAITI
ISCRYHY

Download         Length: 264 bp

>T144949 NZ_CP062247:c1587636-1586314 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9462.65 Da        Isoelectric Point: 5.5802

>AT144949 WP_009836585.1 NZ_CP046794:c159690-159436 [Vibrio metschnikovii]
MRIVSFTEARNSLKSVLDAVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPANAEHLHRSIAQFKAGKVSQRD
LIDE

Download         Length: 255 bp

>AT144949 NZ_CP062247:c1587902-1587636 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5B740

Antitoxin

Source ID Structure
AlphaFold DB A0A7X5B7D9

References