Detailed information of TA system TA144948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 133010..133560
• Replicon: chromosome
• Accession: NZ_CP046794
• Organism: Vibrio metschnikovii strain 9502-00

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1T4SPA2
• Locus tag: GPX86_RS13795
• Protein ID: WP_039428516.1
• Coordinates: 133261..133560 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: GPX86_RS13790
• Protein ID: WP_158145086.1
• Coordinates: 133010..133252 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPX86_RS13755	128077..128253	+	177	Protein_119	IS110 family transposase	-
GPX86_RS13760	128321..129082	-	762	WP_158143699.1	IS21-like element helper ATPase IstB	-
GPX86_RS13765	129069..130109	-	1041	WP_158143698.1	IS21 family transposase	-
GPX86_RS13770	130199..130990	+	792	Protein_122	IS110 family transposase	-
GPX86_RS13775	131065..131355	-	291	WP_002033345.1	hypothetical protein	-
GPX86_RS13780	131843..132166	-	324	WP_158145084.1	hypothetical protein	-
GPX86_RS13785	132302..132793	-	492	WP_158145085.1	HAD-IA family hydrolase	-
GPX86_RS13790	133010..133252	+	243	WP_158145086.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPX86_RS13795	133261..133560	+	300	WP_039428516.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPX86_RS13800	133714..134235	-	522	WP_158145087.1	hypothetical protein	-
GPX86_RS13805	134385..134735	-	351	WP_158145088.1	cupin domain-containing protein	-
GPX86_RS13810	134795..134905	-	111	WP_158145473.1	DUF3265 domain-containing protein	-
GPX86_RS13815	134912..135469	-	558	WP_158145089.1	hypothetical protein	-
GPX86_RS13820	135608..135967	-	360	WP_158145090.1	VOC family protein	-
GPX86_RS13825	136127..137416	-	1290	WP_158145091.1	hypothetical protein	-
GPX86_RS13830	137552..138229	-	678	WP_158145092.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	122740..164003	41263
	-	inside	Integron	-	-	131709..162876	31167

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11622.26 Da
• Isoelectric Point: 9.6429

>T144948 WP_039428516.1 NZ_CP046794:133261-133560 [Vibrio metschnikovii]
MHNKQYKLSSLAQTHLRKVKNYTINNFSELQWQRYKETLLSGFQMLADNPDLGRSCHEIYSNGFYFPIGKHTAYFTKEEN
FILIVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T144948 NZ_CP062247:1504746-1504922 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9150.48 Da
• Isoelectric Point: 5.6850

>AT144948 WP_158145086.1 NZ_CP046794:133010-133252 [Vibrio metschnikovii]
MHTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKTEYLKYCFNAAKDDLAKGNVVEGKDFLNEL

Nucleotide

• Length: 243 bp

>AT144948 NZ_CP062247:1504968-1505384 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A1T4SPA2