Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1991084..1991622 Replicon chromosome
Accession NZ_CP046791
Organism Vibrio navarrensis strain 2462-79

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag GPY30_RS10125 Protein ID WP_158133749.1
Coordinates 1991323..1991622 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag GPY30_RS10120 Protein ID WP_011080384.1
Coordinates 1991084..1991326 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY30_RS10055 1986339..1986464 - 126 WP_001973975.1 DUF3265 domain-containing protein -
GPY30_RS10060 1986914..1987369 - 456 WP_158133740.1 GNAT family N-acetyltransferase -
GPY30_RS10065 1987485..1988021 - 537 WP_158133741.1 GNAT family N-acetyltransferase -
GPY30_RS10070 1988059..1988181 - 123 WP_158133742.1 DUF3265 domain-containing protein -
GPY30_RS10075 1988178..1988702 - 525 WP_158133743.1 GNAT family N-acetyltransferase -
GPY30_RS10080 1988729..1988857 - 129 WP_158133744.1 DUF3265 domain-containing protein -
GPY30_RS10085 1988836..1989279 - 444 WP_158133745.1 hypothetical protein -
GPY30_RS10090 1989295..1989429 - 135 WP_158135045.1 DUF3265 domain-containing protein -
GPY30_RS10095 1989413..1989772 - 360 WP_158133746.1 VOC family protein -
GPY30_RS10100 1989785..1989892 - 108 WP_158133747.1 DUF3265 domain-containing protein -
GPY30_RS10105 1989929..1990408 - 480 WP_158133748.1 hypothetical protein -
GPY30_RS10110 1990441..1990566 - 126 Protein_1942 DUF3265 domain-containing protein -
GPY30_RS10115 1990898..1991050 - 153 WP_072612493.1 DUF3265 domain-containing protein -
GPY30_RS10120 1991084..1991326 + 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GPY30_RS10125 1991323..1991622 + 300 WP_158133749.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY30_RS10130 1991872..1992132 - 261 WP_158135047.1 DUF3709 domain-containing protein -
GPY30_RS10135 1992126..1992287 - 162 WP_158135049.1 DUF3709 domain-containing protein -
GPY30_RS10140 1992268..1992394 - 127 Protein_1948 DUF3265 domain-containing protein -
GPY30_RS10145 1992728..1992913 - 186 WP_158135051.1 DUF3265 domain-containing protein -
GPY30_RS10150 1992846..1993289 - 444 WP_158133750.1 GNAT family N-acetyltransferase -
GPY30_RS10155 1993440..1993835 - 396 WP_158133751.1 VOC family protein -
GPY30_RS10160 1994335..1994478 - 144 WP_158133752.1 DUF3265 domain-containing protein -
GPY30_RS10165 1994509..1995012 - 504 WP_158133753.1 hypothetical protein -
GPY30_RS10170 1995056..1995181 - 126 Protein_1954 DUF3265 domain-containing protein -
GPY30_RS10175 1995524..1995613 - 90 Protein_1955 DUF3265 domain-containing protein -
GPY30_RS10180 1995635..1995916 - 282 WP_158133754.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 / katB 1589386..2075475 486089
- inside Integron - - 1930172..2005096 74924


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(6-92)

Antitoxin

(1-78)


Sequences


Toxin        


Download         Length: 100 a.a.        Molecular weight: 11717.42 Da        Isoelectric Point: 9.9572

>T144946 WP_158133749.1 NZ_CP046791:1991323-1991622 [Vibrio navarrensis]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHIIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T144946 NZ_CP062247:c1267004-1266897 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT144946 WP_011080384.1 NZ_CP046791:1991084-1991326 [Vibrio navarrensis]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT144946 NZ_CP062247:1267051-1267117 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References