Detailed information of TA system TA144944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1857422..1857938
• Replicon: chromosome
• Accession: NZ_CP046791
• Organism: Vibrio navarrensis strain 2462-79

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY30_RS08835
• Protein ID: WP_005492798.1
• Coordinates: 1857422..1857691 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: GPY30_RS08840
• Protein ID: WP_005492799.1
• Coordinates: 1857684..1857938 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY30_RS08780	1852568..1853146	-	579	WP_158133630.1	DJ-1/PfpI family protein	-
GPY30_RS08785	1853173..1853298	-	126	WP_081946574.1	DUF3265 domain-containing protein	-
GPY30_RS08790	1853745..1854176	-	432	WP_158133631.1	hypothetical protein	-
GPY30_RS08795	1854203..1854328	-	126	WP_080252689.1	DUF3265 domain-containing protein	-
GPY30_RS08800	1854670..1854798	-	129	WP_158134981.1	DUF3265 domain-containing protein	-
GPY30_RS08805	1854791..1855159	-	369	WP_017449638.1	VOC family protein	-
GPY30_RS08810	1855189..1855314	-	126	WP_158133632.1	DUF3265 domain-containing protein	-
GPY30_RS08815	1855643..1855765	-	123	Protein_1684	DUF3265 domain-containing protein	-
GPY30_RS08820	1855762..1856793	-	1032	WP_158133633.1	hypothetical protein	-
GPY30_RS08825	1856820..1856945	-	126	WP_158133634.1	DUF3265 domain-containing protein	-
GPY30_RS08830	1857277..1857367	-	91	Protein_1687	DUF3265 domain-containing protein	-
GPY30_RS08835	1857422..1857691	-	270	WP_005492798.1	Txe/YoeB family addiction module toxin	Toxin
GPY30_RS08840	1857684..1857938	-	255	WP_005492799.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GPY30_RS08845	1858153..1858686	-	534	WP_158133635.1	cysteine hydrolase	-
GPY30_RS08850	1858707..1858842	-	136	Protein_1691	DUF3265 domain-containing protein	-
GPY30_RS08855	1859177..1859320	-	144	WP_158133636.1	DUF3265 domain-containing protein	-
GPY30_RS08860	1859302..1859769	-	468	WP_158133637.1	GNAT family N-acetyltransferase	-
GPY30_RS08865	1859898..1860821	-	924	WP_158133638.1	hypothetical protein	-
GPY30_RS08870	1860857..1860946	-	90	WP_158134983.1	DUF3265 domain-containing protein	-
GPY30_RS08875	1860974..1861429	-	456	WP_158133639.1	GNAT family N-acetyltransferase	-
GPY30_RS08880	1861448..1861549	-	102	WP_158134985.1	DUF3265 domain-containing protein	-
GPY30_RS08885	1861567..1862334	-	768	WP_072611833.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	VP1611 / katB	1589386..2075475	486089
	-	inside	Integron	-	-	1759479..1890842	131363

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10557.95 Da
• Isoelectric Point: 8.8578

>T144944 WP_005492798.1 NZ_CP046791:c1857691-1857422 [Vibrio navarrensis]
MSSSQRLLSWTDDAWSDYLYWQTQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAL
TIISCRYHY

Nucleotide

• Length: 270 bp

>T144944 NZ_CP062247:c1265934-1265827 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9498.68 Da
• Isoelectric Point: 5.1007

>AT144944 WP_005492799.1 NZ_CP046791:c1857938-1857684 [Vibrio navarrensis]
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPENAEHLKRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT144944 NZ_CP062247:1265982-1266048 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC