Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 1816353..1816851 Replicon chromosome
Accession NZ_CP046791
Organism Vibrio navarrensis strain 2462-79

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag GPY30_RS08385 Protein ID WP_000589156.1
Coordinates 1816585..1816851 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag GPY30_RS08380 Protein ID WP_000643598.1
Coordinates 1816353..1816598 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY30_RS08335 1811375..1811500 - 126 Protein_1588 DUF3265 domain-containing protein -
GPY30_RS08340 1811843..1811932 - 90 Protein_1589 DUF3265 domain-containing protein -
GPY30_RS08345 1811954..1812235 - 282 WP_158133594.1 hypothetical protein -
GPY30_RS08350 1812269..1812391 - 123 Protein_1591 DUF3265 domain-containing protein -
GPY30_RS08355 1812406..1812882 - 477 WP_158133595.1 VOC family protein -
GPY30_RS08360 1812930..1813373 - 444 WP_158133596.1 GNAT family N-acetyltransferase -
GPY30_RS08365 1813414..1813539 - 126 WP_081946464.1 DUF3265 domain-containing protein -
GPY30_RS08370 1813866..1814006 - 141 WP_158134957.1 DUF3265 domain-containing protein -
GPY30_RS08375 1814436..1815746 - 1311 WP_158134829.1 group II intron reverse transcriptase/maturase -
GPY30_RS08380 1816353..1816598 - 246 WP_000643598.1 hypothetical protein Antitoxin
GPY30_RS08385 1816585..1816851 - 267 WP_000589156.1 BrnT family toxin Toxin
GPY30_RS08390 1816918..1817043 - 126 WP_080007272.1 DUF3265 domain-containing protein -
GPY30_RS08395 1817386..1817511 - 126 WP_158134959.1 DUF3265 domain-containing protein -
GPY30_RS08400 1817842..1817913 - 72 WP_152593318.1 DUF3265 domain-containing protein -
GPY30_RS08405 1818021..1818266 + 246 WP_017420672.1 type II toxin-antitoxin system CcdA family antitoxin -
GPY30_RS08410 1818266..1818583 + 318 WP_158133597.1 CcdB family protein -
GPY30_RS08415 1819042..1819168 - 127 Protein_1604 DUF3265 domain-containing protein -
GPY30_RS08420 1819513..1819644 - 132 WP_158134961.1 DUF3265 domain-containing protein -
GPY30_RS08425 1819651..1819836 - 186 WP_039442689.1 hypothetical protein -
GPY30_RS08430 1819882..1820007 - 126 WP_158133598.1 DUF3265 domain-containing protein -
GPY30_RS08435 1820338..1820460 - 123 WP_158134963.1 DUF3265 domain-containing protein -
GPY30_RS08440 1820463..1821044 - 582 WP_158133599.1 DUF1287 domain-containing protein -
GPY30_RS08445 1821093..1821152 - 60 WP_082798319.1 hypothetical protein -
GPY30_RS08450 1821199..1821492 - 294 WP_158133600.1 Dabb family protein -
GPY30_RS08455 1821510..1821632 - 123 WP_086027501.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 / katB 1589386..2075475 486089
- inside Integron - - 1759479..1890842 131363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T144943 WP_000589156.1 NZ_CP046791:c1816851-1816585 [Vibrio navarrensis]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T144943 NZ_CP062247:c475764-475546 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT144943 WP_000643598.1 NZ_CP046791:c1816598-1816353 [Vibrio navarrensis]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT144943 NZ_CP062247:c476164-475790 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References