Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1777869..1778428 Replicon chromosome
Accession NZ_CP046791
Organism Vibrio navarrensis strain 2462-79

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag GPY30_RS08000 Protein ID WP_000604858.1
Coordinates 1778150..1778428 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GPY30_RS07995 Protein ID WP_000381190.1
Coordinates 1777869..1778153 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY30_RS07935 1773116..1773484 - 369 WP_013571614.1 VOC family protein -
GPY30_RS07940 1773533..1773610 - 78 WP_072606006.1 hypothetical protein -
GPY30_RS07945 1773651..1774100 - 450 WP_158133563.1 GNAT family N-acetyltransferase -
GPY30_RS07950 1774127..1774252 - 126 WP_080391475.1 DUF3265 domain-containing protein -
GPY30_RS07955 1774585..1774674 - 90 WP_140263605.1 DUF3265 domain-containing protein -
GPY30_RS07960 1774718..1775071 - 354 WP_158134927.1 DUF4144 domain-containing protein -
GPY30_RS07965 1775516..1775644 - 129 WP_158134929.1 DUF3265 domain-containing protein -
GPY30_RS07970 1776480..1776770 - 291 WP_079400291.1 YkgJ family cysteine cluster protein -
GPY30_RS07975 1776869..1776994 - 126 WP_158133564.1 DUF3265 domain-containing protein -
GPY30_RS07980 1777007..1777192 - 186 WP_140304466.1 hypothetical protein -
GPY30_RS07985 1777238..1777363 - 126 WP_114710093.1 DUF3265 domain-containing protein -
GPY30_RS07990 1777688..1777822 - 135 WP_158133565.1 DUF3265 domain-containing protein -
GPY30_RS07995 1777869..1778153 + 285 WP_000381190.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY30_RS08000 1778150..1778428 + 279 WP_000604858.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY30_RS08005 1778578..1778877 - 300 WP_061897955.1 antibiotic biosynthesis monooxygenase -
GPY30_RS08010 1779368..1779490 - 123 WP_158134931.1 DUF3265 domain-containing protein -
GPY30_RS08015 1779525..1780286 - 762 WP_158133566.1 nucleotidyltransferase domain-containing protein -
GPY30_RS08020 1780318..1780443 - 126 WP_158133567.1 DUF3265 domain-containing protein -
GPY30_RS08025 1780831..1781382 - 552 WP_158133568.1 class IV adenylate cyclase -
GPY30_RS08030 1781458..1781583 - 126 WP_158133569.1 DUF3265 domain-containing protein -
GPY30_RS08035 1782859..1782984 - 126 WP_081946699.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - VP1611 / katB 1589386..2075475 486089
- inside Integron - - 1759479..1890842 131363


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-74)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11020.76 Da        Isoelectric Point: 4.4548

>T144941 WP_000604858.1 NZ_CP046791:1778150-1778428 [Vibrio navarrensis]
MILWEEESLNDREKIFEFLHDFNPDAAERTDEIIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGDFIRIM
RVLHQKQKFPMY

Download         Length: 279 bp

>T144941 NZ_CP062247:248788-249186 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10909.31 Da        Isoelectric Point: 9.1865

>AT144941 WP_000381190.1 NZ_CP046791:1777869-1778153 [Vibrio navarrensis]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKAVFVDHESAKAR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT144941 NZ_CP062247:248492-248785 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References