Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafN(antitoxin)
Location 2368754..2369319 Replicon chromosome
Accession NZ_CP046787
Organism Vibrio parahaemolyticus strain 2013V-1174

Toxin (Protein)


Gene name relE Uniprot ID A0A2N7N9G2
Locus tag GPY29_RS11855 Protein ID WP_029840597.1
Coordinates 2368754..2369041 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2N7N9N2
Locus tag GPY29_RS11860 Protein ID WP_025633738.1
Coordinates 2369038..2369319 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY29_RS11810 2364411..2364938 - 528 WP_049876715.1 GNAT family N-acetyltransferase -
GPY29_RS11815 2364950..2365042 - 93 WP_079749978.1 DUF3265 domain-containing protein -
GPY29_RS11820 2365067..2365975 - 909 WP_049876717.1 TIR domain-containing protein -
GPY29_RS11825 2366121..2366480 - 360 WP_029841057.1 VOC family protein -
GPY29_RS11835 2366641..2366988 - 348 WP_029840795.1 hypothetical protein -
GPY29_RS11840 2367016..2367126 - 111 WP_079750055.1 DUF3265 domain-containing protein -
GPY29_RS11845 2367123..2367464 - 342 WP_029840797.1 hypothetical protein -
GPY29_RS11850 2367615..2368103 - 489 WP_029840800.1 hypothetical protein -
GPY29_RS11855 2368754..2369041 - 288 WP_029840597.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY29_RS11860 2369038..2369319 - 282 WP_025633738.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY29_RS11865 2369642..2369950 + 309 WP_197580052.1 thiamine-binding protein -
GPY29_RS11870 2369987..2370109 - 123 WP_079749993.1 DUF3265 domain-containing protein -
GPY29_RS11880 2370452..2370580 - 129 WP_079749991.1 DUF3265 domain-containing protein -
GPY29_RS11885 2370602..2370820 - 219 WP_021453865.1 hypothetical protein -
GPY29_RS11890 2370937..2371050 - 114 WP_194295466.1 DUF3265 domain-containing protein -
GPY29_RS25460 2371485..2371576 - 92 Protein_2142 DUF3265 domain-containing protein -
GPY29_RS11905 2371591..2372100 - 510 WP_031781899.1 GNAT family N-acetyltransferase -
GPY29_RS25465 2372138..2372254 - 117 WP_170827217.1 DUF3265 domain-containing protein -
GPY29_RS11910 2372244..2372759 - 516 WP_031781898.1 hypothetical protein -
GPY29_RS11915 2372790..2372882 - 93 WP_079749987.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 2311652..2400219 88567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-74)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10959.59 Da        Isoelectric Point: 4.7860

>T144937 WP_029840597.1 NZ_CP046787:c2369041-2368754 [Vibrio parahaemolyticus]
MNVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTELLSSMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV

Download         Length: 288 bp

>T144937 NZ_CP062246:4438509-4438859 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10426.96 Da        Isoelectric Point: 5.8719

>AT144937 WP_025633738.1 NZ_CP046787:c2369319-2369038 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRLKK

Download         Length: 282 bp

>AT144937 NZ_CP062246:4438264-4438515 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7N9G2

Antitoxin

Source ID Structure
AlphaFold DB A0A2N7N9N2

References