Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 2450147..2450675 | Replicon | chromosome |
| Accession | NZ_CP046785 | ||
| Organism | Vibrio parahaemolyticus strain 2013V-1136 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | GPY45_RS12425 | Protein ID | WP_089202913.1 |
| Coordinates | 2450147..2450437 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR02 |
| Locus tag | GPY45_RS12430 | Protein ID | WP_005377003.1 |
| Coordinates | 2450427..2450675 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY45_RS12400 | 2446526..2447449 | + | 924 | WP_020838889.1 | zinc dependent phospholipase C family protein | - |
| GPY45_RS12405 | 2447446..2447844 | + | 399 | WP_023623455.1 | hypothetical protein | - |
| GPY45_RS12410 | 2448003..2448959 | + | 957 | WP_089202915.1 | hypothetical protein | - |
| GPY45_RS12415 | 2449410..2449571 | + | 162 | WP_141106043.1 | DUF3265 domain-containing protein | - |
| GPY45_RS12420 | 2449586..2450020 | + | 435 | WP_089202914.1 | GNAT family N-acetyltransferase | - |
| GPY45_RS12425 | 2450147..2450437 | - | 291 | WP_089202913.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY45_RS12430 | 2450427..2450675 | - | 249 | WP_005377003.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPY45_RS12435 | 2450939..2451640 | + | 702 | WP_089202912.1 | hypothetical protein | - |
| GPY45_RS12440 | 2451792..2452328 | + | 537 | WP_089202911.1 | hypothetical protein | - |
| GPY45_RS12445 | 2452543..2452791 | + | 249 | WP_069496061.1 | hypothetical protein | - |
| GPY45_RS12450 | 2452792..2452914 | + | 123 | WP_079877554.1 | DUF3265 domain-containing protein | - |
| GPY45_RS12455 | 2452953..2453366 | + | 414 | WP_089202910.1 | hypothetical protein | - |
| GPY45_RS12460 | 2453403..2453492 | + | 90 | WP_072599486.1 | DUF3265 domain-containing protein | - |
| GPY45_RS12465 | 2453524..2454210 | + | 687 | WP_069496218.1 | hypothetical protein | - |
| GPY45_RS12470 | 2454236..2454328 | + | 93 | WP_079877572.1 | DUF3265 domain-containing protein | - |
| GPY45_RS12475 | 2454849..2454938 | + | 90 | WP_074534792.1 | DUF3265 domain-containing protein | - |
| GPY45_RS12480 | 2455162..2455659 | + | 498 | WP_089202909.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | vpadF / vpadF / vxsC / virG / exsA / exsD / vscB / vscC / vscD / vscF / vscG / vscH / vscI / vscJ / vscK / vscL / vopS / vopR / vecA / vopQ / vscU / vscT / vscS / vscR / vscQ / vscP / vscO / vscN / vopN / tyeA/vcr1 / sycN/vcr2 / vscX / vscY / vcrD / vcrR / vcrG / vcrV / vcrH / vopB / vopD / VP1611 | 2322112..2711902 | 389790 | |
| - | inside | Integron | - | - | 2397971..2490093 | 92122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11262.19 Da Isoelectric Point: 10.4350
>T144936 WP_089202913.1 NZ_CP046785:c2450437-2450147 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMERLDD
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMERLDD
Download Length: 291 bp
>T144936 NZ_CP062246:4342725-4342898 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 83 a.a. Molecular weight: 9079.37 Da Isoelectric Point: 3.9610
>AT144936 WP_005377003.1 NZ_CP046785:c2450675-2450427 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL
Download Length: 249 bp
>AT144936 NZ_CP062246:4342401-4342697 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|