Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1391308..1391867 Replicon chromosome
Accession NZ_CP046783
Organism Vibrio parahaemolyticus strain 2013V-1181

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR22
Locus tag GPY39_RS06985 Protein ID WP_005398411.1
Coordinates 1391589..1391867 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag GPY39_RS06980 Protein ID WP_005398409.1
Coordinates 1391308..1391592 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY39_RS06940 1386473..1386790 - 318 WP_021448742.1 hypothetical protein -
GPY39_RS06950 1387433..1387846 - 414 WP_021448743.1 hypothetical protein -
GPY39_RS06955 1388059..1388232 - 174 WP_021448744.1 hypothetical protein -
GPY39_RS06960 1388324..1388881 - 558 WP_021448745.1 hypothetical protein -
GPY39_RS06965 1389639..1390100 - 462 WP_021448746.1 DUF1851 domain-containing protein -
GPY39_RS06970 1390130..1390252 - 123 WP_108702465.1 DUF3265 domain-containing protein -
GPY39_RS06975 1390781..1391119 - 339 WP_021448749.1 hypothetical protein -
GPY39_RS06980 1391308..1391592 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY39_RS06985 1391589..1391867 + 279 WP_005398411.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY39_RS06990 1392003..1392362 - 360 WP_021448750.1 DUF2750 domain-containing protein -
GPY39_RS07000 1392501..1393379 - 879 WP_021448752.1 hypothetical protein -
GPY39_RS07005 1393530..1394072 - 543 WP_079765068.1 hypothetical protein -
GPY39_RS07015 1394584..1394676 - 93 WP_193386937.1 DUF3265 domain-containing protein -
GPY39_RS07020 1395131..1395223 - 93 WP_079765067.1 DUF3265 domain-containing protein -
GPY39_RS07025 1395251..1395709 - 459 WP_025613401.1 hypothetical protein -
GPY39_RS07030 1395737..1395826 - 90 WP_079765069.1 DUF3265 domain-containing protein -
GPY39_RS07035 1396201..1396279 - 79 Protein_1301 DUF3265 domain-containing protein -
GPY39_RS07040 1396308..1396805 - 498 WP_021448757.1 DNA topology modulation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - vopD / vopB / vcrH / vcrV / vcrG / vcrR / vcrD / vscY / vscX / sycN/vcr2 / tyeA/vcr1 / vopN / vscN / vscO / vscP / vscQ / vscR / vscS / vscT / vscU / vopQ / vecA / vopR / vopS / vscL / vscK / vscJ / vscI / vscH / vscG / vscF / vscD / vscC / vscB / exsD / exsA / virG / vxsC 1180789..1553514 372725
- inside Integron - - 1336067..1457133 121066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10891.57 Da        Isoelectric Point: 4.3430

>T144933 WP_005398411.1 NZ_CP046783:1391589-1391867 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T144933 NZ_CP062246:c3227814-3227500 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT144933 WP_005398409.1 NZ_CP046783:1391308-1391592 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT144933 NZ_CP062246:c3227503-3227087 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR22

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References