Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 2541620..2542185 | Replicon | chromosome |
| Accession | NZ_CP046779 | ||
| Organism | Vibrio parahaemolyticus strain 2014V-1066 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W588 |
| Locus tag | GPY25_RS12875 | Protein ID | WP_023667331.1 |
| Coordinates | 2541620..2541907 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | GPY25_RS12880 | Protein ID | WP_023667330.1 |
| Coordinates | 2541904..2542185 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY25_RS12815 | 2536999..2537091 | - | 93 | WP_078535095.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12820 | 2537127..2537579 | - | 453 | WP_005494814.1 | hypothetical protein | - |
| GPY25_RS12825 | 2537613..2537702 | - | 90 | WP_078235921.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12835 | 2538376..2538585 | - | 210 | WP_025506672.1 | DUF3955 domain-containing protein | - |
| GPY25_RS12840 | 2538687..2538779 | - | 93 | WP_005494807.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12845 | 2539142..2539270 | - | 129 | WP_161612914.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12850 | 2539270..2539737 | - | 468 | WP_005494803.1 | GNAT family N-acetyltransferase | - |
| GPY25_RS12855 | 2539756..2539878 | - | 123 | WP_079748760.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12860 | 2540889..2541020 | - | 132 | WP_005494795.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12870 | 2541501..2541617 | - | 117 | WP_078532102.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12875 | 2541620..2541907 | - | 288 | WP_023667331.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY25_RS12880 | 2541904..2542185 | - | 282 | WP_023667330.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPY25_RS12885 | 2542395..2542886 | - | 492 | WP_029850189.1 | hypothetical protein | - |
| GPY25_RS12890 | 2542915..2542992 | - | 78 | WP_079748784.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12895 | 2543026..2543442 | - | 417 | WP_023667328.1 | VOC family protein | - |
| GPY25_RS12905 | 2544659..2545240 | - | 582 | WP_023667325.1 | putative mannitol operon repressor domain protein | - |
| GPY25_RS12910 | 2545268..2545357 | - | 90 | WP_079748783.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12915 | 2545381..2545737 | - | 357 | WP_021485171.1 | hypothetical protein | - |
| GPY25_RS12920 | 2545784..2545876 | - | 93 | WP_079748814.1 | DUF3265 domain-containing protein | - |
| GPY25_RS12925 | 2545891..2546475 | - | 585 | WP_029850554.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2453663..2556113 | 102450 | |
| - | inside | Integron | - | - | 2453530..2554402 | 100872 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10949.53 Da Isoelectric Point: 5.0980
>T144932 WP_023667331.1 NZ_CP046779:c2541907-2541620 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV
Download Length: 288 bp
>T144932 NZ_CP062246:c3161903-3161607 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10427.94 Da Isoelectric Point: 5.1991
>AT144932 WP_023667330.1 NZ_CP046779:c2542185-2541904 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK
Download Length: 282 bp
>AT144932 NZ_CP062246:c3161605-3161210 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|