Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2535842..2536370 Replicon chromosome
Accession NZ_CP046779
Organism Vibrio parahaemolyticus strain 2014V-1066

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag GPY25_RS12805 Protein ID WP_005377002.1
Coordinates 2536080..2536370 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR02
Locus tag GPY25_RS12800 Protein ID WP_005377003.1
Coordinates 2535842..2536090 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY25_RS12765 2531156..2531542 - 387 WP_021447429.1 NUDIX hydrolase -
GPY25_RS12770 2532149..2532670 - 522 WP_005494827.1 GNAT family N-acetyltransferase -
GPY25_RS12775 2533295..2533918 - 624 WP_005494825.1 hypothetical protein -
GPY25_RS12780 2533962..2534093 - 132 WP_005494822.1 DUF3265 domain-containing protein -
GPY25_RS12790 2534583..2534675 - 93 WP_005494820.1 DUF3265 domain-containing protein -
GPY25_RS12795 2534690..2535094 - 405 WP_005494818.1 hypothetical protein -
GPY25_RS12800 2535842..2536090 + 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY25_RS12805 2536080..2536370 + 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY25_RS12810 2536389..2536478 - 90 WP_077680412.1 DUF3265 domain-containing protein -
GPY25_RS12815 2536999..2537091 - 93 WP_078535095.1 DUF3265 domain-containing protein -
GPY25_RS12820 2537127..2537579 - 453 WP_005494814.1 hypothetical protein -
GPY25_RS12825 2537613..2537702 - 90 WP_078235921.1 DUF3265 domain-containing protein -
GPY25_RS12835 2538376..2538585 - 210 WP_025506672.1 DUF3955 domain-containing protein -
GPY25_RS12840 2538687..2538779 - 93 WP_005494807.1 DUF3265 domain-containing protein -
GPY25_RS12845 2539142..2539270 - 129 WP_161612914.1 DUF3265 domain-containing protein -
GPY25_RS12850 2539270..2539737 - 468 WP_005494803.1 GNAT family N-acetyltransferase -
GPY25_RS12855 2539756..2539878 - 123 WP_079748760.1 DUF3265 domain-containing protein -
GPY25_RS12860 2540889..2541020 - 132 WP_005494795.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2453663..2556113 102450
- inside Integron - - 2453530..2554402 100872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-75)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T144931 WP_005377002.1 NZ_CP046779:2536080-2536370 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T144931 NZ_CP062246:c3034182-3033775 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9079.37 Da        Isoelectric Point: 3.9610

>AT144931 WP_005377003.1 NZ_CP046779:2535842-2536090 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT144931 NZ_CP062246:c3034429-3034163 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR02

References