Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2509493..2510052 Replicon chromosome
Accession NZ_CP046779
Organism Vibrio parahaemolyticus strain 2014V-1066

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5L8
Locus tag GPY25_RS12575 Protein ID WP_005497247.1
Coordinates 2509774..2510052 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2ZGZ5
Locus tag GPY25_RS12570 Protein ID WP_005497249.1
Coordinates 2509493..2509777 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY25_RS12530 2504968..2505057 - 90 WP_079740873.1 DUF3265 domain-containing protein -
GPY25_RS12535 2505075..2505551 - 477 WP_005500215.1 GNAT family N-acetyltransferase -
GPY25_RS12540 2505730..2505933 - 204 WP_025793489.1 hypothetical protein -
GPY25_RS12545 2506554..2506646 - 93 WP_069518749.1 DUF3265 domain-containing protein -
GPY25_RS12550 2506666..2507079 - 414 WP_005500273.1 hypothetical protein -
GPY25_RS12555 2507186..2507878 - 693 WP_127463323.1 hypothetical protein -
GPY25_RS12560 2508223..2508582 - 360 WP_005497251.1 hypothetical protein -
GPY25_RS12565 2508768..2509325 - 558 WP_005497250.1 nucleotidyltransferase domain-containing protein -
GPY25_RS12570 2509493..2509777 + 285 WP_005497249.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY25_RS12575 2509774..2510052 + 279 WP_005497247.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY25_RS12580 2510081..2510173 - 93 WP_072036351.1 DUF3265 domain-containing protein -
GPY25_RS12585 2510188..2510907 - 720 WP_021447410.1 hypothetical protein -
GPY25_RS12590 2511529..2512197 - 669 WP_005497242.1 GIY-YIG nuclease family protein -
GPY25_RS12595 2512755..2512846 - 92 Protein_2243 DUF3265 domain-containing protein -
GPY25_RS12600 2512861..2513370 - 510 WP_021447337.1 GNAT family N-acetyltransferase -
GPY25_RS12605 2513407..2513496 - 90 WP_079748782.1 DUF3265 domain-containing protein -
GPY25_RS12610 2513520..2513876 - 357 WP_021485171.1 hypothetical protein -
GPY25_RS12615 2514031..2514465 - 435 WP_020838880.1 GNAT family N-acetyltransferase -
GPY25_RS12620 2514512..2514604 - 93 WP_079748755.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2453663..2556113 102450
- inside Integron - - 2453530..2554402 100872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10914.61 Da        Isoelectric Point: 4.4755

>T144930 WP_005497247.1 NZ_CP046779:2509774-2510052 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDEVIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPVS

Download         Length: 279 bp

>T144930 NZ_CP062246:c2904450-2904115 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10913.25 Da        Isoelectric Point: 9.1865

>AT144930 WP_005497249.1 NZ_CP046779:2509493-2509777 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT144930 NZ_CP062246:c2904698-2904450 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5L8

Antitoxin

Source ID Structure
AlphaFold DB U2ZGZ5

References