Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2459166..2459713 Replicon chromosome
Accession NZ_CP046779
Organism Vibrio parahaemolyticus strain 2014V-1066

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5B6
Locus tag GPY25_RS12110 Protein ID WP_005500333.1
Coordinates 2459166..2459468 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag GPY25_RS12115 Protein ID WP_005448240.1
Coordinates 2459456..2459713 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY25_RS12070 2455884..2456174 - 291 WP_005500341.1 YkgJ family cysteine cluster protein -
GPY25_RS12075 2456441..2456725 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY25_RS12080 2456722..2457000 + 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY25_RS25350 2457029..2457163 - 135 WP_161612893.1 DUF3265 domain-containing protein -
GPY25_RS12090 2457124..2457477 - 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
GPY25_RS12095 2457626..2458465 - 840 WP_005500335.1 hypothetical protein -
GPY25_RS12100 2458622..2458990 - 369 WP_005500334.1 VOC family protein -
GPY25_RS12105 2459038..2459127 - 90 WP_072828861.1 DUF3265 domain-containing protein -
GPY25_RS12110 2459166..2459468 - 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY25_RS12115 2459456..2459713 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY25_RS12120 2459795..2459863 - 69 WP_079748735.1 DUF3265 domain-containing protein -
GPY25_RS12130 2460471..2460668 - 198 WP_005500332.1 hypothetical protein -
GPY25_RS12135 2461375..2461812 - 438 WP_005500331.1 GIY-YIG nuclease family protein -
GPY25_RS12140 2461838..2461930 - 93 WP_005500330.1 DUF3265 domain-containing protein -
GPY25_RS12145 2461945..2462454 - 510 WP_005500328.1 hypothetical protein -
GPY25_RS12150 2462464..2462574 - 111 WP_079861117.1 DUF3265 domain-containing protein -
GPY25_RS12155 2462581..2462961 - 381 WP_005487927.1 TonB family protein -
GPY25_RS12160 2462991..2463158 - 168 WP_086027883.1 DUF3265 domain-containing protein -
GPY25_RS12165 2463098..2463394 - 297 WP_005500327.1 hypothetical protein -
GPY25_RS12170 2463425..2463514 - 90 WP_079748734.1 DUF3265 domain-containing protein -
GPY25_RS12175 2463546..2463818 - 273 WP_005462157.1 nicotinamide mononucleotide transporter -
GPY25_RS12180 2463845..2463955 - 111 WP_082798391.1 DUF3265 domain-containing protein -
GPY25_RS12185 2463963..2464247 - 285 WP_005500325.1 nucleotide pyrophosphohydrolase -
GPY25_RS12190 2464292..2464384 - 93 WP_193268598.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2453663..2556113 102450
- inside Integron - - 2453530..2554402 100872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.65 Da        Isoelectric Point: 6.9806

>T144929 WP_005500333.1 NZ_CP046779:c2459468-2459166 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T144929 NZ_CP062246:2770812-2771141 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT144929 WP_005448240.1 NZ_CP046779:c2459713-2459456 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT144929 NZ_CP062246:2770474-2770791 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5B6

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References