Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2456441..2457000 Replicon chromosome
Accession NZ_CP046779
Organism Vibrio parahaemolyticus strain 2014V-1066

Toxin (Protein)


Gene name relE Uniprot ID A0A249W573
Locus tag GPY25_RS12080 Protein ID WP_005500338.1
Coordinates 2456722..2457000 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A347UR21
Locus tag GPY25_RS12075 Protein ID WP_005398409.1
Coordinates 2456441..2456725 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY25_RS12050 2452046..2452507 - 462 WP_005500350.1 hypothetical protein -
GPY25_RS12055 2452849..2453295 + 447 WP_005500348.1 DUF3291 domain-containing protein -
GPY25_RS12060 2453663..2454034 - 372 Protein_2143 pyridoxamine 5'-phosphate oxidase family protein -
GPY25_RS12070 2455884..2456174 - 291 WP_005500341.1 YkgJ family cysteine cluster protein -
GPY25_RS12075 2456441..2456725 + 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY25_RS12080 2456722..2457000 + 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY25_RS25350 2457029..2457163 - 135 WP_161612893.1 DUF3265 domain-containing protein -
GPY25_RS12090 2457124..2457477 - 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
GPY25_RS12095 2457626..2458465 - 840 WP_005500335.1 hypothetical protein -
GPY25_RS12100 2458622..2458990 - 369 WP_005500334.1 VOC family protein -
GPY25_RS12105 2459038..2459127 - 90 WP_072828861.1 DUF3265 domain-containing protein -
GPY25_RS12110 2459166..2459468 - 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin -
GPY25_RS12115 2459456..2459713 - 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GPY25_RS12120 2459795..2459863 - 69 WP_079748735.1 DUF3265 domain-containing protein -
GPY25_RS12130 2460471..2460668 - 198 WP_005500332.1 hypothetical protein -
GPY25_RS12135 2461375..2461812 - 438 WP_005500331.1 GIY-YIG nuclease family protein -
GPY25_RS12140 2461838..2461930 - 93 WP_005500330.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2453663..2556113 102450
- inside Integron - - 2453530..2554402 100872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10878.53 Da        Isoelectric Point: 4.2597

>T144928 WP_005500338.1 NZ_CP046779:2456722-2457000 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T144928 NZ_CP062246:2759277-2760350 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11069.40 Da        Isoelectric Point: 9.2167

>AT144928 WP_005398409.1 NZ_CP046779:2456441-2456725 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Download         Length: 285 bp

>AT144928 NZ_CP062246:2760343-2760714 [Escherichia coli]
TTGTTTGAAATCACCGGAATTAACGTCTCAGGGGCTCTAAAAGCTGTCGTTATGGCGACCGGCTTCGAGAACCCTTTGTC
CTCAGTTAATGAAATTGAGACGAAACTTTCTGCCCTACTGGGTAGTGAGACCACTGGTGAAATCCTTTTTGACCTCTTGT
GCGCTAACGGTCCAGAGTGGAACCGCTTCGTTACGCTGGAAATGAAATATGGCCGGATCATGCTGGATACGGCCAAAATT
ATTGATGAGCAGGACGTTCCGACACATATCCTGAGCAAACTGACTTTTACTTTACGTAATCATCCTGAGTACCTAGAAGC
CTCTGTTTTGTCTCCCGATGATGTACGCCAAGTCCTGTCAATGGATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W573

Antitoxin

Source ID Structure
AlphaFold DB A0A347UR21

References