Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 3100024..3100571 Replicon chromosome
Accession NZ_CP046778
Organism Vibrio parahaemolyticus strain 2014V-1125

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5B6
Locus tag GPY34_RS24285 Protein ID WP_005500333.1
Coordinates 3100269..3100571 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag GPY34_RS24280 Protein ID WP_005448240.1
Coordinates 3100024..3100281 (+) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY34_RS24205 3095353..3095445 + 93 WP_193268598.1 DUF3265 domain-containing protein -
GPY34_RS24210 3095490..3095774 + 285 WP_005500325.1 nucleotide pyrophosphohydrolase -
GPY34_RS24215 3095782..3095892 + 111 WP_082798391.1 DUF3265 domain-containing protein -
GPY34_RS24220 3095919..3096191 + 273 WP_005462157.1 nicotinamide mononucleotide transporter -
GPY34_RS24225 3096223..3096312 + 90 WP_079748734.1 DUF3265 domain-containing protein -
GPY34_RS24230 3096343..3096639 + 297 WP_005500327.1 hypothetical protein -
GPY34_RS24235 3096579..3096746 + 168 WP_086027883.1 DUF3265 domain-containing protein -
GPY34_RS24240 3096776..3097156 + 381 WP_005487927.1 TonB family protein -
GPY34_RS24245 3097163..3097273 + 111 WP_079861117.1 DUF3265 domain-containing protein -
GPY34_RS24250 3097283..3097792 + 510 WP_005500328.1 hypothetical protein -
GPY34_RS24255 3097807..3097899 + 93 WP_005500330.1 DUF3265 domain-containing protein -
GPY34_RS24260 3097925..3098362 + 438 WP_005500331.1 GIY-YIG nuclease family protein -
GPY34_RS24265 3099069..3099266 + 198 WP_005500332.1 hypothetical protein -
GPY34_RS24275 3099874..3099942 + 69 WP_079748735.1 DUF3265 domain-containing protein -
GPY34_RS24280 3100024..3100281 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GPY34_RS24285 3100269..3100571 + 303 WP_005500333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GPY34_RS24290 3100610..3100699 + 90 WP_072828861.1 DUF3265 domain-containing protein -
GPY34_RS24295 3100747..3101115 + 369 WP_005500334.1 VOC family protein -
GPY34_RS24300 3101272..3102111 + 840 WP_005500335.1 hypothetical protein -
GPY34_RS24305 3102260..3102613 + 354 WP_005500336.1 glyoxalase/bleomycin resistance/dioxygenase family protein -
GPY34_RS25425 3102574..3102708 + 135 WP_161612893.1 DUF3265 domain-containing protein -
GPY34_RS24315 3102737..3103015 - 279 WP_005500338.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GPY34_RS24320 3103012..3103296 - 285 WP_005398409.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GPY34_RS24325 3103563..3103853 + 291 WP_005500341.1 YkgJ family cysteine cluster protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3004811..3106888 102077
- inside Integron - - 3005335..3106207 100872


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11682.65 Da        Isoelectric Point: 6.9806

>T144926 WP_005500333.1 NZ_CP046778:3100269-3100571 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T144926 NZ_CP062246:c2082946-2082692 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT144926 WP_005448240.1 NZ_CP046778:3100024-3100281 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT144926 NZ_CP062246:c2083194-2082943 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A249W5B6


Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References