Detailed information of TA system TA144924

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3023367..3023895
• Replicon: chromosome
• Accession: NZ_CP046778
• Organism: Vibrio parahaemolyticus strain 2014V-1125

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K5TRR0
• Locus tag: GPY34_RS23590
• Protein ID: WP_005377002.1
• Coordinates: 3023367..3023657 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: GPY34_RS23595
• Protein ID: WP_005377003.1
• Coordinates: 3023647..3023895 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY34_RS23535	3018717..3018848	+	132	WP_005494795.1	DUF3265 domain-containing protein	-
GPY34_RS23540	3019859..3019981	+	123	WP_079748760.1	DUF3265 domain-containing protein	-
GPY34_RS23545	3020000..3020467	+	468	WP_005494803.1	GNAT family N-acetyltransferase	-
GPY34_RS23550	3020467..3020595	+	129	WP_161612914.1	DUF3265 domain-containing protein	-
GPY34_RS23555	3020958..3021050	+	93	WP_005494807.1	DUF3265 domain-containing protein	-
GPY34_RS23560	3021152..3021361	+	210	WP_025506672.1	DUF3955 domain-containing protein	-
GPY34_RS23570	3022035..3022124	+	90	WP_078235921.1	DUF3265 domain-containing protein	-
GPY34_RS23575	3022158..3022610	+	453	WP_005494814.1	hypothetical protein	-
GPY34_RS23580	3022646..3022738	+	93	WP_078535095.1	DUF3265 domain-containing protein	-
GPY34_RS23585	3023259..3023348	+	90	WP_077680412.1	DUF3265 domain-containing protein	-
GPY34_RS23590	3023367..3023657	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY34_RS23595	3023647..3023895	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY34_RS23600	3024643..3025047	+	405	WP_005494818.1	hypothetical protein	-
GPY34_RS23605	3025062..3025154	+	93	WP_005494820.1	DUF3265 domain-containing protein	-
GPY34_RS23615	3025644..3025775	+	132	WP_005494822.1	DUF3265 domain-containing protein	-
GPY34_RS23620	3025819..3026442	+	624	WP_005494825.1	hypothetical protein	-
GPY34_RS23625	3027067..3027588	+	522	WP_005494827.1	GNAT family N-acetyltransferase	-
GPY34_RS23630	3028195..3028581	+	387	WP_021447429.1	NUDIX hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3004811..3106888	102077
	-	inside	Integron	-	-	3005335..3106207	100872

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11261.25 Da
• Isoelectric Point: 10.5932

>T144924 WP_005377002.1 NZ_CP046778:c3023657-3023367 [Vibrio parahaemolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T144924 NZ_CP062246:c1917464-1917361 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT144924 WP_005377003.1 NZ_CP046778:c3023895-3023647 [Vibrio parahaemolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT144924 NZ_CP062246:1917323-1917594 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Toxin

• AlphaFold DB: A0A347UR03

Antitoxin

• AlphaFold DB: A0A347UR02