Detailed information of TA system TA144922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1409562..1410111
• Replicon: chromosome
• Accession: NZ_CP046776
• Organism: Vibrio parahaemolyticus strain AM43962

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GPY46_RS16090
• Protein ID: WP_025506692.1
• Coordinates: 1409562..1409861 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A347UQT2
• Locus tag: GPY46_RS16095
• Protein ID: WP_005442033.1
• Coordinates: 1409869..1410111 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY46_RS16050	1404621..1405340	+	720	WP_025506355.1	hypothetical protein	-
GPY46_RS16055	1405728..1405895	+	168	WP_077673150.1	DUF3265 domain-containing protein	-
GPY46_RS16060	1405924..1406523	+	600	WP_025506358.1	hypothetical protein	-
GPY46_RS16065	1406527..1406832	+	306	WP_025506359.1	hypothetical protein	-
GPY46_RS16070	1407234..1407392	+	159	WP_180758365.1	DUF3265 domain-containing protein	-
GPY46_RS16075	1407409..1408053	+	645	WP_025506675.1	hypothetical protein	-
GPY46_RS16080	1408287..1408664	+	378	WP_025506701.1	hypothetical protein	-
GPY46_RS16085	1408920..1409012	+	93	WP_140068266.1	DUF3265 domain-containing protein	-
GPY46_RS16090	1409562..1409861	-	300	WP_025506692.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY46_RS16095	1409869..1410111	-	243	WP_005442033.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY46_RS16100	1410186..1410311	+	126	WP_162484483.1	DUF3265 domain-containing protein	-
GPY46_RS16105	1410779..1410889	+	111	WP_078511339.1	DUF3265 domain-containing protein	-
GPY46_RS16110	1410900..1411343	+	444	WP_025604650.1	hypothetical protein	-
GPY46_RS16115	1411808..1412041	+	234	Protein_1346	IS481 family transposase	-
GPY46_RS16120	1412156..1413415	-	1260	WP_158127747.1	DUF4056 domain-containing protein	-
GPY46_RS16125	1413421..1414602	-	1182	WP_025636132.1	BamA/TamA family outer membrane protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	dfrA6	VP1611	1271226..1700734	429508
	-	inside	Integron	-	-	1348292..1410324	62032

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-55)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11601.20 Da
• Isoelectric Point: 8.0278

>T144922 WP_025506692.1 NZ_CP046776:c1409861-1409562 [Vibrio parahaemolyticus]
MQRNKYKLSNLAQSHLRKVKDYTVENFSELQWRNYKDTLLSGFQMLADNPDLGRSCDEIYPNGFYFPIGKHTAYFIKEDD
FILVVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T144922 NZ_CP062246:c1586433-1585111 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9047.26 Da
• Isoelectric Point: 5.6926

>AT144922 WP_005442033.1 NZ_CP046776:c1410111-1409869 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDTVVVMSIRDFEELEAMKVEYLKHCFKSAKEDLNNGNTVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT144922 NZ_CP062246:c1586699-1586433 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A347UQT2