Detailed information of TA system TA144918

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2057933..2058461
• Replicon: chromosome
• Accession: NZ_CP046772
• Organism: Vibrio alginolyticus strain 2014V-1011

Toxin (Protein)

• Gene name: relE
• Uniprot ID: K5TRR0
• Locus tag: GPY59_RS17950
• Protein ID: WP_005377002.1
• Coordinates: 2058171..2058461 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR02
• Locus tag: GPY59_RS17945
• Protein ID: WP_005377003.1
• Coordinates: 2057933..2058181 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY59_RS26105	2053042..2053134	-	93	WP_078555029.1	DUF3265 domain-containing protein	-
GPY59_RS17895	2053149..2053709	-	561	WP_158173959.1	hypothetical protein	-
GPY59_RS26110	2053750..2053842	-	93	WP_080259164.1	DUF3265 domain-containing protein	-
GPY59_RS17905	2053866..2054363	-	498	WP_158173961.1	hypothetical protein	-
GPY59_RS17910	2054501..2055100	-	600	WP_158173962.1	glutathione S-transferase N-terminal domain-containing protein	-
GPY59_RS17915	2055129..2055260	-	132	WP_158173963.1	DUF3265 domain-containing protein	-
GPY59_RS17925	2055748..2055840	-	93	WP_005494820.1	DUF3265 domain-containing protein	-
GPY59_RS17930	2056310..2056402	-	93	WP_199266728.1	DUF3265 domain-containing protein	-
GPY59_RS17935	2056417..2057189	-	773	Protein_1833	NERD domain-containing protein	-
GPY59_RS17940	2057766..2057858	-	93	WP_199266729.1	DUF3265 domain-containing protein	-
GPY59_RS17945	2057933..2058181	+	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY59_RS17950	2058171..2058461	+	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY59_RS17955	2058480..2058593	-	114	Protein_1837	DUF3265 domain-containing protein	-
GPY59_RS17960	2058611..2059012	-	402	WP_031778946.1	hypothetical protein	-
GPY59_RS17965	2059177..2059269	-	93	WP_140316205.1	DUF3265 domain-containing protein	-
GPY59_RS17970	2059348..2060100	-	753	WP_158173964.1	HNH endonuclease	-
GPY59_RS17975	2060302..2060856	-	555	WP_158173965.1	hypothetical protein	-
GPY59_RS17980	2061001..2061756	-	756	WP_158173966.1	hypothetical protein	-
GPY59_RS17985	2061921..2063165	-	1245	WP_158173967.1	SIR2 family protein	-
GPY59_RS17990	2063226..2063378	-	153	WP_078236020.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2025588..2131457	105869
	-	inside	Integron	-	-	2034766..2130339	95573

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11261.25 Da
• Isoelectric Point: 10.5932

>T144918 WP_005377002.1 NZ_CP046772:2058171-2058461 [Vibrio alginolyticus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T144918 NZ_CP062246:c1265266-1265159 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9079.37 Da
• Isoelectric Point: 3.9610

>AT144918 WP_005377003.1 NZ_CP046772:2057933-2058181 [Vibrio alginolyticus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLAIAKERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT144918 NZ_CP062246:1265313-1265379 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A347UR03

Antitoxin

• AlphaFold DB: A0A347UR02