Detailed information of TA system TA144917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 3305486..3306002
• Replicon: chromosome
• Accession: NZ_CP046763
• Organism: Vibrio parahaemolyticus strain 2012AW-0353

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY19_RS16545
• Protein ID: WP_031778247.1
• Coordinates: 3305486..3305755 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A7W4CB60
• Locus tag: GPY19_RS16550
• Protein ID: WP_005483180.1
• Coordinates: 3305748..3306002 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY19_RS16500	3301009..3301332	-	324	WP_154119766.1	hypothetical protein	-
GPY19_RS16505	3301375..3301467	-	93	WP_154119768.1	DUF3265 domain-containing protein	-
GPY19_RS16510	3301513..3302037	-	525	WP_154119770.1	AAA family ATPase	-
GPY19_RS16515	3302082..3302216	-	135	WP_154120037.1	DUF3265 domain-containing protein	-
GPY19_RS16520	3302213..3302596	-	384	WP_154119772.1	GFA family protein	-
GPY19_RS16525	3303230..3303733	-	504	WP_154119774.1	hypothetical protein	-
GPY19_RS16530	3303730..3303897	-	168	WP_195723295.1	DUF3265 domain-containing protein	-
GPY19_RS16535	3303867..3304490	-	624	WP_154119776.1	hypothetical protein	-
GPY19_RS16540	3304628..3305323	-	696	WP_154119778.1	hypothetical protein	-
GPY19_RS16545	3305486..3305755	-	270	WP_031778247.1	Txe/YoeB family addiction module toxin	Toxin
GPY19_RS16550	3305748..3306002	-	255	WP_005483180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GPY19_RS16555	3306105..3306197	-	93	WP_076664760.1	DUF3265 domain-containing protein	-
GPY19_RS16560	3306223..3306924	-	702	WP_158131209.1	hypothetical protein	-
GPY19_RS16565	3307086..3307457	-	372	WP_072611945.1	hypothetical protein	-
GPY19_RS16570	3307504..3307593	-	90	WP_079750700.1	DUF3265 domain-containing protein	-
GPY19_RS16575	3307622..3308329	-	708	WP_138937910.1	hypothetical protein	-
GPY19_RS16580	3308357..3308482	-	126	WP_080256126.1	DUF3265 domain-containing protein	-
GPY19_RS16585	3308810..3308938	-	129	WP_158131216.1	DUF3265 domain-containing protein	-
GPY19_RS16590	3309488..3309919	-	432	WP_017049022.1	GNAT family N-acetyltransferase	-
GPY19_RS16595	3310127..3310453	-	327	WP_031778052.1	hypothetical protein	-
GPY19_RS16600	3310501..3310593	-	93	WP_005445235.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	3197020..3317093	120073

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (10-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10641.04 Da
• Isoelectric Point: 7.9816

>T144917 WP_031778247.1 NZ_CP046763:c3305755-3305486 [Vibrio parahaemolyticus]
MSSSQRLLLWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY

Nucleotide

• Length: 270 bp

>T144917 NZ_CP062246:c1264731-1264624 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9481.66 Da
• Isoelectric Point: 5.0623

>AT144917 WP_005483180.1 NZ_CP046763:c3306002-3305748 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT144917 NZ_CP062246:1264779-1264845 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Structures

Antitoxin

• AlphaFold DB: A0A7W4CB60