Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 3200480..3200996 | Replicon | chromosome |
| Accession | NZ_CP046763 | ||
| Organism | Vibrio parahaemolyticus strain 2012AW-0353 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | GPY19_RS15445 | Protein ID | WP_031778247.1 |
| Coordinates | 3200480..3200749 (-) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A7W4CB60 |
| Locus tag | GPY19_RS15450 | Protein ID | WP_005483180.1 |
| Coordinates | 3200742..3200996 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY19_RS15415 | 3196553..3196986 | - | 434 | Protein_2768 | GNAT family N-acetyltransferase | - |
| GPY19_RS15420 | 3197165..3197575 | - | 411 | WP_024701711.1 | hypothetical protein | - |
| GPY19_RS15425 | 3197656..3198546 | - | 891 | WP_005485669.1 | hypothetical protein | - |
| GPY19_RS15430 | 3198733..3198788 | - | 56 | Protein_2771 | DUF3265 domain-containing protein | - |
| GPY19_RS15435 | 3199157..3199957 | - | 801 | WP_086482363.1 | IS3 family transposase | - |
| GPY19_RS15440 | 3200041..3200262 | - | 222 | Protein_2773 | transposase | - |
| GPY19_RS15445 | 3200480..3200749 | - | 270 | WP_031778247.1 | Txe/YoeB family addiction module toxin | Toxin |
| GPY19_RS15450 | 3200742..3200996 | - | 255 | WP_005483180.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| GPY19_RS15455 | 3201220..3201486 | - | 267 | WP_005464625.1 | hypothetical protein | - |
| GPY19_RS15460 | 3201774..3201929 | - | 156 | Protein_2777 | SDR family oxidoreductase | - |
| GPY19_RS15465 | 3201996..3203146 | + | 1151 | WP_102978303.1 | IS3 family transposase | - |
| GPY19_RS15470 | 3203159..3203755 | - | 597 | WP_078532239.1 | type I restriction enzyme HsdR N-terminal domain-containing protein | - |
| GPY19_RS15475 | 3203852..3203944 | - | 93 | WP_078532240.1 | DUF3265 domain-containing protein | - |
| GPY19_RS15480 | 3203967..3204383 | - | 417 | WP_025507116.1 | hypothetical protein | - |
| GPY19_RS15485 | 3204520..3205008 | - | 489 | WP_025549022.1 | hypothetical protein | - |
| GPY19_RS15490 | 3205048..3205128 | - | 81 | WP_078532227.1 | DUF3265 domain-containing protein | - |
| GPY19_RS15495 | 3205143..3205565 | - | 423 | WP_025523873.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3192316..3212599 | 20283 | |
| - | inside | Integron | - | - | 3197020..3317093 | 120073 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10641.04 Da Isoelectric Point: 7.9816
>T144915 WP_031778247.1 NZ_CP046763:c3200749-3200480 [Vibrio parahaemolyticus]
MSSSQRLLLWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLLWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRIDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T144915 NZ_CP062246:c259380-259039 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9481.66 Da Isoelectric Point: 5.0623
>AT144915 WP_005483180.1 NZ_CP046763:c3200996-3200742 [Vibrio parahaemolyticus]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNVEHLNRSIAQYRAGKTTARE
LIDE
Download Length: 255 bp
>AT144915 NZ_CP062246:c259718-259401 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|