Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE-RelB |
| Location | 1276353..1276912 | Replicon | chromosome |
| Accession | NZ_CP046754 | ||
| Organism | Vibrio parahaemolyticus strain 2015AW-0174 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W573 |
| Locus tag | GPY21_RS15355 | Protein ID | WP_005500338.1 |
| Coordinates | 1276353..1276631 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A347UR21 |
| Locus tag | GPY21_RS15360 | Protein ID | WP_005398409.1 |
| Coordinates | 1276628..1276912 (-) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY21_RS15295 | 1271423..1271515 | + | 93 | WP_005500330.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15300 | 1271541..1271978 | + | 438 | WP_005500331.1 | GIY-YIG nuclease family protein | - |
| GPY21_RS15305 | 1272685..1272882 | + | 198 | WP_005500332.1 | hypothetical protein | - |
| GPY21_RS15315 | 1273490..1273558 | + | 69 | WP_079748735.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15320 | 1273640..1273897 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| GPY21_RS15325 | 1273885..1274187 | + | 303 | WP_005500333.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| GPY21_RS15330 | 1274226..1274315 | + | 90 | WP_072828861.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15335 | 1274363..1274731 | + | 369 | WP_005500334.1 | VOC family protein | - |
| GPY21_RS15340 | 1274888..1275727 | + | 840 | WP_005500335.1 | hypothetical protein | - |
| GPY21_RS15345 | 1275876..1276229 | + | 354 | WP_005500336.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| GPY21_RS25425 | 1276190..1276324 | + | 135 | WP_161612893.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15355 | 1276353..1276631 | - | 279 | WP_005500338.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| GPY21_RS15360 | 1276628..1276912 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| GPY21_RS15365 | 1277179..1277469 | + | 291 | WP_005500341.1 | YkgJ family cysteine cluster protein | - |
| GPY21_RS15370 | 1278137..1279287 | + | 1151 | WP_088337786.1 | IS3 family transposase | - |
| GPY21_RS15375 | 1279321..1279689 | + | 369 | Protein_1192 | pyridoxamine 5'-phosphate oxidase family protein | - |
| GPY21_RS15380 | 1280057..1280503 | - | 447 | WP_005500348.1 | DUF3291 domain-containing protein | - |
| GPY21_RS15385 | 1280845..1281306 | + | 462 | WP_005500350.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1175272..1280503 | 105231 | |
| - | inside | Integron | - | - | 1175796..1279822 | 104026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10878.53 Da Isoelectric Point: 4.2597
>T144913 WP_005500338.1 NZ_CP046754:c1276631-1276353 [Vibrio parahaemolyticus]
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
MILWEEESLDDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQPLMGVQRDGIRGRLLIIPDISMIVSYWVEGDIIRVM
RVLHQKQKFPTD
Download Length: 279 bp
>T144913 NZ_CP062246:c242726-242448 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 95 a.a. Molecular weight: 11069.40 Da Isoelectric Point: 9.2167
>AT144913 WP_005398409.1 NZ_CP046754:c1276912-1276628 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ
Download Length: 285 bp
>AT144913 NZ_CP062246:c242989-242729 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249W573 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A347UR21 |