Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1273640..1274187 | Replicon | chromosome |
| Accession | NZ_CP046754 | ||
| Organism | Vibrio parahaemolyticus strain 2015AW-0174 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W5B6 |
| Locus tag | GPY21_RS15325 | Protein ID | WP_005500333.1 |
| Coordinates | 1273885..1274187 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | GPY21_RS15320 | Protein ID | WP_005448240.1 |
| Coordinates | 1273640..1273897 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GPY21_RS15245 | 1268969..1269061 | + | 93 | WP_193268598.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15250 | 1269106..1269390 | + | 285 | WP_005500325.1 | nucleotide pyrophosphohydrolase | - |
| GPY21_RS15255 | 1269398..1269508 | + | 111 | WP_082798391.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15260 | 1269535..1269807 | + | 273 | WP_005462157.1 | nicotinamide mononucleotide transporter | - |
| GPY21_RS15265 | 1269839..1269928 | + | 90 | WP_079748734.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15270 | 1269959..1270255 | + | 297 | WP_005500327.1 | hypothetical protein | - |
| GPY21_RS15275 | 1270195..1270362 | + | 168 | WP_086027883.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15280 | 1270392..1270772 | + | 381 | WP_005487927.1 | TonB family protein | - |
| GPY21_RS15285 | 1270779..1270889 | + | 111 | WP_079861117.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15290 | 1270899..1271408 | + | 510 | WP_005500328.1 | hypothetical protein | - |
| GPY21_RS15295 | 1271423..1271515 | + | 93 | WP_005500330.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15300 | 1271541..1271978 | + | 438 | WP_005500331.1 | GIY-YIG nuclease family protein | - |
| GPY21_RS15305 | 1272685..1272882 | + | 198 | WP_005500332.1 | hypothetical protein | - |
| GPY21_RS15315 | 1273490..1273558 | + | 69 | WP_079748735.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15320 | 1273640..1273897 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GPY21_RS15325 | 1273885..1274187 | + | 303 | WP_005500333.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GPY21_RS15330 | 1274226..1274315 | + | 90 | WP_072828861.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15335 | 1274363..1274731 | + | 369 | WP_005500334.1 | VOC family protein | - |
| GPY21_RS15340 | 1274888..1275727 | + | 840 | WP_005500335.1 | hypothetical protein | - |
| GPY21_RS15345 | 1275876..1276229 | + | 354 | WP_005500336.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| GPY21_RS25425 | 1276190..1276324 | + | 135 | WP_161612893.1 | DUF3265 domain-containing protein | - |
| GPY21_RS15355 | 1276353..1276631 | - | 279 | WP_005500338.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| GPY21_RS15360 | 1276628..1276912 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| GPY21_RS15365 | 1277179..1277469 | + | 291 | WP_005500341.1 | YkgJ family cysteine cluster protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1175272..1280503 | 105231 | |
| - | inside | Integron | - | - | 1175796..1279822 | 104026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11682.65 Da Isoelectric Point: 6.9806
>T144912 WP_005500333.1 NZ_CP046754:1273885-1274187 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T144912 NZ_CP062245:c4569656-4569315 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT144912 WP_005448240.1 NZ_CP046754:1273640-1273897 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT144912 NZ_CP062245:4569651-4569727 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249W5B6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A432DGX8 |