Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1223301..1223860 Replicon chromosome
Accession NZ_CP046754
Organism Vibrio parahaemolyticus strain 2015AW-0174

Toxin (Protein)


Gene name relE Uniprot ID A0A249W5L8
Locus tag GPY21_RS14845 Protein ID WP_005497247.1
Coordinates 1223301..1223579 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U2ZGZ5
Locus tag GPY21_RS14850 Protein ID WP_005497249.1
Coordinates 1223576..1223860 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPY21_RS14800 1218749..1218841 + 93 WP_079748755.1 DUF3265 domain-containing protein -
GPY21_RS14805 1218888..1219322 + 435 WP_020838880.1 GNAT family N-acetyltransferase -
GPY21_RS14810 1219477..1219833 + 357 WP_021485171.1 hypothetical protein -
GPY21_RS14815 1219857..1219946 + 90 WP_079748782.1 DUF3265 domain-containing protein -
GPY21_RS14820 1219983..1220492 + 510 WP_021447337.1 GNAT family N-acetyltransferase -
GPY21_RS14825 1220507..1220598 + 92 Protein_1090 DUF3265 domain-containing protein -
GPY21_RS14830 1221156..1221824 + 669 WP_005497242.1 GIY-YIG nuclease family protein -
GPY21_RS14835 1222446..1223165 + 720 WP_021447410.1 hypothetical protein -
GPY21_RS14840 1223180..1223272 + 93 WP_072036351.1 DUF3265 domain-containing protein -
GPY21_RS14845 1223301..1223579 - 279 WP_005497247.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GPY21_RS14850 1223576..1223860 - 285 WP_005497249.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GPY21_RS14855 1224028..1224585 + 558 WP_005497250.1 nucleotidyltransferase domain-containing protein -
GPY21_RS14860 1224771..1225130 + 360 WP_005497251.1 hypothetical protein -
GPY21_RS14865 1225307..1226167 + 861 WP_139791852.1 hypothetical protein -
GPY21_RS14870 1226274..1226687 + 414 WP_005500273.1 hypothetical protein -
GPY21_RS14875 1226707..1226799 + 93 WP_069518749.1 DUF3265 domain-containing protein -
GPY21_RS14880 1227420..1227623 + 204 WP_025793489.1 hypothetical protein -
GPY21_RS14885 1227802..1228278 + 477 WP_005500215.1 GNAT family N-acetyltransferase -
GPY21_RS14890 1228296..1228385 + 90 WP_079740873.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1175272..1280503 105231
- inside Integron - - 1175796..1279822 104026


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10914.61 Da        Isoelectric Point: 4.4755

>T144911 WP_005497247.1 NZ_CP046754:c1223579-1223301 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAAEKTDEVIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPVS

Download         Length: 279 bp

>T144911 NZ_CP062245:c4523869-4523612 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10913.25 Da        Isoelectric Point: 9.1865

>AT144911 WP_005497249.1 NZ_CP046754:c1223860-1223576 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL

Download         Length: 285 bp

>AT144911 NZ_CP062245:c4523600-4523055 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249W5L8

Antitoxin

Source ID Structure
AlphaFold DB U2ZGZ5

References