Detailed information of TA system TA144909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1191168..1191733
• Replicon: chromosome
• Accession: NZ_CP046754
• Organism: Vibrio parahaemolyticus strain 2015AW-0174

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A249W588
• Locus tag: GPY21_RS14545
• Protein ID: WP_023667331.1
• Coordinates: 1191446..1191733 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GPY21_RS14540
• Protein ID: WP_023667330.1
• Coordinates: 1191168..1191449 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPY21_RS14495	1186878..1187462	+	585	WP_029850554.1	hypothetical protein	-
GPY21_RS14500	1187477..1187569	+	93	WP_079748814.1	DUF3265 domain-containing protein	-
GPY21_RS14505	1187616..1187972	+	357	WP_021485171.1	hypothetical protein	-
GPY21_RS14510	1187996..1188085	+	90	WP_079748783.1	DUF3265 domain-containing protein	-
GPY21_RS14515	1188113..1188694	+	582	WP_023667325.1	putative mannitol operon repressor domain protein	-
GPY21_RS14525	1189911..1190327	+	417	WP_023667328.1	VOC family protein	-
GPY21_RS14530	1190361..1190438	+	78	WP_079748784.1	DUF3265 domain-containing protein	-
GPY21_RS14535	1190467..1190958	+	492	WP_029850189.1	hypothetical protein	-
GPY21_RS14540	1191168..1191449	+	282	WP_023667330.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GPY21_RS14545	1191446..1191733	+	288	WP_023667331.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GPY21_RS14550	1191736..1191852	+	117	WP_078532102.1	DUF3265 domain-containing protein	-
GPY21_RS14560	1192333..1192464	+	132	WP_005494795.1	DUF3265 domain-containing protein	-
GPY21_RS14565	1193475..1193597	+	123	WP_079748760.1	DUF3265 domain-containing protein	-
GPY21_RS14570	1193616..1194083	+	468	WP_005494803.1	GNAT family N-acetyltransferase	-
GPY21_RS14575	1194083..1194211	+	129	WP_161612914.1	DUF3265 domain-containing protein	-
GPY21_RS14580	1194574..1194666	+	93	WP_005494807.1	DUF3265 domain-containing protein	-
GPY21_RS14585	1194768..1194977	+	210	WP_025506672.1	DUF3955 domain-containing protein	-
GPY21_RS14595	1195651..1195740	+	90	WP_078235921.1	DUF3265 domain-containing protein	-
GPY21_RS14600	1195774..1196226	+	453	WP_005494814.1	hypothetical protein	-
GPY21_RS14605	1196262..1196354	+	93	WP_078535095.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1175272..1280503	105231
	-	inside	Integron	-	-	1175796..1279822	104026

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10949.53 Da
• Isoelectric Point: 5.0980

>T144909 WP_023667331.1 NZ_CP046754:1191446-1191733 [Vibrio parahaemolyticus]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNDVFDKTESLGSMPEMGRFVPEIPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQILTEDDV

Nucleotide

• Length: 288 bp

>T144909 NZ_CP062245:4342724-4342897 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10427.94 Da
• Isoelectric Point: 5.1991

>AT144909 WP_023667330.1 NZ_CP046754:1191168-1191449 [Vibrio parahaemolyticus]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EEARAEVLGRIKK

Nucleotide

• Length: 282 bp

>AT144909 NZ_CP062245:4342400-4342696 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A249W588